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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/ijerph13100990 http://scihub22266oqcxt.onion/10.3390/ijerph13100990 C5086729!5086729 !27739415     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27739415 &cmd=llinks): Failed to open stream: HTTP request failed! 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Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells via Activation of the JNK Pathway |pdf=|usr=}}{{27739415 }} gab.com Text Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells via Activation of the JNK Pathway JO: Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=27739415 #FOAvip Cadmium (Cd) is a heavy metal and environmental pollutant. The kidney is the principal target organ of Cd exposure. Previously, we found that low concentration of Cd damages the integrity of the glomerular filtration barrier. However, little is known about the effects of Cd on renal mesangial cells, which provide structural support for the glomerular capillary loops and regulate intraglomerular blood flow. In this study, human renal mesangial cells (HRMCs) were cultured in the presence of serum and treated with 4 ?M Cd. We found that Cd activates the c-Jun N-terminal kinase (JNK) pathway, and increases the protein levels of c-Jun and c-Fos. Cd treatment also induces a decrease in proliferation and an increase in apoptosis of HRMCs, but only the decrease in HRMC proliferation was reversed by pretreatment with SP600125, an inhibitor of the JNK pathway. In addition, Cd does not change the expression of ?-smooth muscle actin and platelet-derived growth factor receptor-?, the markers of mesangial cells, or the alignment of the filamentous actin (F-actin) cytoskeleton of HRMCs. Our data indicate that the JNK pathway mediates the inhibitory effects of Cd on HRMC proliferation. Twit Text FOAVip Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells via Activation of the JNK Pathway ????Int J Environ Res Public Health http://www.kidney.de/pget.php?&tw=1&pmid=27739415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27739415 #FOAvip English Wikipedia <ref>{{Cite pmid|27739415 }}</ref> Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells via Activation of the JNK Pathway #MMPMID27739415 Chen X ; Li J ; Cheng Z ; Xu Y ; Wang X ; Li X ; Xu D ; Kapron CM ; Liu J Int J Environ Res Public Health 2016[Oct]; 13 (10 ): ä PMID27739415 show ga Cadmium (Cd) is a heavy metal and environmental pollutant. The kidney is the principal target organ of Cd exposure. Previously, we found that low concentration of Cd damages the integrity of the glomerular filtration barrier. However, little is known about the effects of Cd on renal mesangial cells, which provide structural support for the glomerular capillary loops and regulate intraglomerular blood flow. In this study, human renal mesangial cells (HRMCs) were cultured in the presence of serum and treated with 4 ?M Cd. We found that Cd activates the c-Jun N-terminal kinase (JNK) pathway, and increases the protein levels of c-Jun and c-Fos. Cd treatment also induces a decrease in proliferation and an increase in apoptosis of HRMCs, but only the decrease in HRMC proliferation was reversed by pretreatment with SP600125, an inhibitor of the JNK pathway. In addition, Cd does not change the expression of ?-smooth muscle actin and platelet-derived growth factor receptor-?, the markers of mesangial cells, or the alignment of the filamentous actin (F-actin) cytoskeleton of HRMCs. Our data indicate that the JNK pathway mediates the inhibitory effects of Cd on HRMC proliferation. |*Dose-Response Relationship, Drug [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Cadmium/*administration & dosage/*pharmacology [MESH] |Cell Proliferation/*drug effects [MESH] |Cells, Cultured [MESH] |Environmental Pollutants/pharmacology [MESH] |Humans [MESH] |JNK Mitogen-Activated Protein Kinases/*drug effects [MESH] |MAP Kinase Signaling System [MESH]Low Dose Cadmium Inhibits Proliferation of Human Renal Mesangial Cells(epmc).pdf DeepDyve Pubget Overpricing