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10.3390/toxins8100305 http://scihub22266oqcxt.onion/10.3390/toxins8100305 C5086665!5086665!27782085     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxins+(Basel) 2016 ; 8 (10): ä Nephropedia Template TP {{tp|p=27782085|t=2016. Structure, Biology, and Therapeutic Application of Toxin?Antitoxin Systems in Pathogenic Bacteria |pdf=|usr=}}{{27782085}} gab.com Text Structure, Biology, and Therapeutic Application of Toxin Antitoxin Systems in Pathogenic Bacteria JO: Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27782085 #FOAvip Bacterial toxin?antitoxin (TA) systems have received increasing attention for their diverse identities, structures, and functional implications in cell cycle arrest and survival against environmental stresses such as nutrient deficiency, antibiotic treatments, and immune system attacks. In this review, we describe the biological functions and the auto-regulatory mechanisms of six different types of TA systems, among which the type II TA system has been most extensively studied. The functions of type II toxins include mRNA/tRNA cleavage, gyrase/ribosome poison, and protein phosphorylation, which can be neutralized by their cognate antitoxins. We mainly explore the similar but divergent structures of type II TA proteins from 12 important pathogenic bacteria, including various aspects of protein?protein interactions. Accumulating knowledge about the structure?function correlation of TA systems from pathogenic bacteria has facilitated a novel strategy to develop antibiotic drugs that target specific pathogens. These molecules could increase the intrinsic activity of the toxin by artificially interfering with the intermolecular network of the TA systems. Twit Text FOAVip Structure, Biology, and Therapeutic Application of Toxin Antitoxin Systems in Pathogenic Bacteria ????Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27782085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27782085 #FOAvip English Wikipedia <ref>{{Cite pmid|27782085}}</ref> Structure, Biology, and Therapeutic Application of Toxin?Antitoxin Systems in Pathogenic Bacteria #MMPMID27782085 Lee KY; Lee BJ Toxins (Basel) 2016[Oct]; 8 (10): ä PMID27782085show ga Bacterial toxin?antitoxin (TA) systems have received increasing attention for their diverse identities, structures, and functional implications in cell cycle arrest and survival against environmental stresses such as nutrient deficiency, antibiotic treatments, and immune system attacks. In this review, we describe the biological functions and the auto-regulatory mechanisms of six different types of TA systems, among which the type II TA system has been most extensively studied. The functions of type II toxins include mRNA/tRNA cleavage, gyrase/ribosome poison, and protein phosphorylation, which can be neutralized by their cognate antitoxins. We mainly explore the similar but divergent structures of type II TA proteins from 12 important pathogenic bacteria, including various aspects of protein?protein interactions. Accumulating knowledge about the structure?function correlation of TA systems from pathogenic bacteria has facilitated a novel strategy to develop antibiotic drugs that target specific pathogens. These molecules could increase the intrinsic activity of the toxin by artificially interfering with the intermolecular network of the TA systems. äStructure, Biology, and Therapeutic Application of Toxin?Antitoxin Sys(epmc).pdf DeepDyve Pubget Overpricing