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2016 ; 8
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): ä Nephropedia Template TP
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English Wikipedia
Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet
Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites
#MMPMID27690102
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; Koh CY
Toxins (Basel)
2016[Sep]; 8
(10
): ä PMID27690102
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Snake venom metalloproteases, in addition to their contribution to the digestion
of the prey, affect various physiological functions by cleaving specific
proteins. They exhibit their activities through activation of zymogens of
coagulation factors, and precursors of integrins or receptors. Based on their
structure-function relationships and mechanism of action, we have defined
classification and nomenclature of functional sites of proteases. These
metalloproteases are useful as research tools and in diagnosis and treatment of
various thrombotic and hemostatic conditions. They also contribute to our
understanding of molecular details in the activation of specific factors involved
in coagulation, platelet aggregation and matrix biology. This review provides a
ready reference for metalloproteases that interfere in blood coagulation,
fibrinolysis and platelet aggregation.