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2016 ; 8
(10
): ä Nephropedia Template TP
Viruses
2016[Oct]; 8
(10
): ä PMID27727184
show ga
Morbilliviruses share considerable structural and functional similarities. Even
though disease severity varies among the respective host species, the underlying
pathogenesis and the clinical signs are comparable. Thus, insights gained with
one morbillivirus often apply to the other members of the genus. Since the Canine
distemper virus (CDV) causes severe and often lethal disease in dogs and ferrets,
it is an attractive model to characterize morbillivirus pathogenesis mechanisms
and to evaluate the efficacy of new prophylactic and therapeutic approaches. This
review compares the cellular tropism, pathogenesis, mechanisms of persistence and
immunosuppression of the Measles virus (MeV) and CDV. It then summarizes the
contributions made by studies on the CDV in dogs and ferrets to our understanding
of MeV pathogenesis and to vaccine and drugs development.