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10.1128/MCB.00311-16 http://scihub22266oqcxt.onion/10.1128/MCB.00311-16 C5086522!5086522!27550814     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Biol 2016 ; 36 (22): 2811-23 Nephropedia Template TP {{tp|p=27550814|t=2016. Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis |pdf=|usr=}}{{27550814}} gab.com Text Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27550814 #FOAvip Proper regulation of epithelial cell turnover is important for the structural integrity and homeostasis of various tissues, including the intestine. Here we show that ablation of Csk, a negative regulator of Src family kinases (SFKs), specifically in intestinal epithelial cells (IECs) resulted in the development of hyperplasia throughout the intestinal epithelium of mice. Such conditional ablation of Csk also increased the proliferative activity and turnover of IECs, disturbed the differentiation of Paneth and goblet cells, reduced the number of intestinal stem cells, and attenuated the expression of Wnt target genes in the intestine. Moreover, the tyrosine phosphorylation of focal adhesion kinase (FAK) and the activities of both Rac and Yes-associated protein (YAP) were increased in intestinal crypts or organoids of the mutant mice, whereas inhibition of Rac or YAP activity rescued the mutant phenotypes. Our results thus suggest that SFKs promote the proliferation of IECs in intestinal crypts through activation of Rac or YAP and that they thereby contribute to the proper regulation of IEC turnover and intestinal homeostasis. Twit Text FOAVip Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27550814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27550814 #FOAvip English Wikipedia <ref>{{Cite pmid|27550814}}</ref> Role of Src Family Kinases in Regulation of Intestinal Epithelial Homeostasis #MMPMID27550814 Imada S; Murata Y; Kotani T; Hatano M; Sun C; Konno T; Park Jh; Kitamura Y; Saito Y; Ohdan H; Matozaki T Mol Cell Biol 2016[Nov]; 36 (22): 2811-23 PMID27550814show ga Proper regulation of epithelial cell turnover is important for the structural integrity and homeostasis of various tissues, including the intestine. Here we show that ablation of Csk, a negative regulator of Src family kinases (SFKs), specifically in intestinal epithelial cells (IECs) resulted in the development of hyperplasia throughout the intestinal epithelium of mice. Such conditional ablation of Csk also increased the proliferative activity and turnover of IECs, disturbed the differentiation of Paneth and goblet cells, reduced the number of intestinal stem cells, and attenuated the expression of Wnt target genes in the intestine. Moreover, the tyrosine phosphorylation of focal adhesion kinase (FAK) and the activities of both Rac and Yes-associated protein (YAP) were increased in intestinal crypts or organoids of the mutant mice, whereas inhibition of Rac or YAP activity rescued the mutant phenotypes. Our results thus suggest that SFKs promote the proliferation of IECs in intestinal crypts through activation of Rac or YAP and that they thereby contribute to the proper regulation of IEC turnover and intestinal homeostasis. äRole of Src Family Kinases in Regulation of Intestinal Epithelial Home(epmc).pdf DeepDyve Pubget Overpricing