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10.1186/s12859-016-1297-x http://scihub22266oqcxt.onion/10.1186/s12859-016-1297-x C5086070!5086070 !27793081     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27793081 &cmd=llinks): Failed to open stream: HTTP request failed! 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An analysis of simple computational strategies to facilitate the design of functional molecular information processors |pdf=|usr=}}{{27793081 }} gab.com Text An analysis of simple computational strategies to facilitate the design of functional molecular information processors JO: BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=27793081 #FOAvip BACKGROUND: Biological macromolecules (DNA, RNA and proteins) are capable of processing physical or chemical inputs to generate outputs that parallel conventional Boolean logical operators. However, the design of functional modules that will enable these macromolecules to operate as synthetic molecular computing devices is challenging. RESULTS: Using three simple heuristics, we designed RNA sensors that can mimic the function of a seven-segment display (SSD). Ten independent and orthogonal sensors representing the numerals 0 to 9 are designed and constructed. Each sensor has its own unique oligonucleotide binding site region that is activated uniquely by a specific input. Each operator was subjected to a stringent in silico filtering. Random sensors were selected and functionally validated via ribozyme self cleavage assays that were visualized via electrophoresis. CONCLUSIONS: By utilising simple permutation and randomisation in the sequence design phase, we have developed functional RNA sensors thus demonstrating that even the simplest of computational methods can greatly aid the design phase for constructing functional molecular devices. Twit Text FOAVip An analysis of simple computational strategies to facilitate the design of functional molecular information processors ????BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=27793081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27793081 #FOAvip English Wikipedia <ref>{{Cite pmid|27793081 }}</ref> An analysis of simple computational strategies to facilitate the design of functional molecular information processors #MMPMID27793081 Lee Y ; Roslan R ; Azizan S ; Firdaus-Raih M ; Ramlan EI BMC Bioinformatics 2016[Oct]; 17 (1 ): 438 PMID27793081 show ga BACKGROUND: Biological macromolecules (DNA, RNA and proteins) are capable of processing physical or chemical inputs to generate outputs that parallel conventional Boolean logical operators. However, the design of functional modules that will enable these macromolecules to operate as synthetic molecular computing devices is challenging. RESULTS: Using three simple heuristics, we designed RNA sensors that can mimic the function of a seven-segment display (SSD). Ten independent and orthogonal sensors representing the numerals 0 to 9 are designed and constructed. Each sensor has its own unique oligonucleotide binding site region that is activated uniquely by a specific input. Each operator was subjected to a stringent in silico filtering. Random sensors were selected and functionally validated via ribozyme self cleavage assays that were visualized via electrophoresis. CONCLUSIONS: By utilising simple permutation and randomisation in the sequence design phase, we have developed functional RNA sensors thus demonstrating that even the simplest of computational methods can greatly aid the design phase for constructing functional molecular devices. |Computational Biology/*instrumentation/*methods [MESH] |Computer Simulation [MESH] |Electrophoresis, Polyacrylamide Gel [MESH] |RNA, Catalytic/metabolism [MESH] |RNA/*chemistry [MESH]An analysis of simple computational strategies to facilitate the desig(epmc).pdf DeepDyve Pubget Overpricing