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10.1016/j.jpeds.2016.08.027 http://scihub22266oqcxt.onion/10.1016/j.jpeds.2016.08.027 C5085847!5085847!27574996     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pediatr 2016 ; 178 (ä): 254-260.e4 Nephropedia Template TP {{tp|p=27574996|t=2016. Hypercalcemia in Patients with Williams-Beuren Syndrome |pdf=|usr=}}{{27574996}} gab.com Text Hypercalcemia in Patients with Williams-Beuren Syndrome JO: J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=27574996 #FOAvip Objective: To evaluate the timing, trajectory, and implications of hypercalcemia in Williams-Beuren syndrome (WBS) through a multicenter retrospective study. Study design: Data on plasma calcium levels from 232 subjects with WBS aged 0?67.1 years were compared with that in controls and also with available normative data. Association testing was used to identify relevant comorbidities. Results: On average, individuals with WBS had higher plasma calcium levels than controls, but 86.7% of values were normal. Nonpediatric laboratories overreport hypercalcemia in small children. When pediatric reference intervals were applied, the occurrence of hypercalcemia dropped by 51% in infants and by 38% in toddlers. Across all ages, 6.1% of the subjects had actionable hypercalcemia. In children, actionable hypercalcemia was seen in those aged 5?25 months. In older individuals, actionable hypercalcemia was often secondary to another disease process. Evidence of dehydration, hypercalciuria, and nephrocalcinosis were common in both groups. Future hypercalcemia could not be reliably predicted by screening calcium levels. A subgroup analysis of 91 subjects found no associations between hypercalcemia and cardiovascular disease, gastrointestinal complaints, or renal anomalies. Analyses of electrogradiography data showed an inverse correlation of calcium concentration with corrected QT interval, but no acute life-threatening events were reported. Conclusions: Actionable hypercalcemia in patients with WBS occurs infrequently. Although irritability and lethargy were commonly reported, no mortality or acute life-threatening events were associated with hypercalcemia and the only statistically associated morbidities were dehydration, hypercalciuria, and nephrocalcinosis. Twit Text FOAVip Hypercalcemia in Patients with Williams-Beuren Syndrome ????J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=27574996 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27574996 #FOAvip English Wikipedia <ref>{{Cite pmid|27574996}}</ref> Hypercalcemia in Patients with Williams-Beuren Syndrome #MMPMID27574996 Sindhar S; Lugo M; Levin MD; Danback JR; Brink BD; Yu E; Dietzen DJ; Clark AL; Purgert CA; Waxler JL; Elder RW; Pober BR; Kozel BA J Pediatr 2016[Nov]; 178 (ä): 254-260.e4 PMID27574996show ga Objective: To evaluate the timing, trajectory, and implications of hypercalcemia in Williams-Beuren syndrome (WBS) through a multicenter retrospective study. Study design: Data on plasma calcium levels from 232 subjects with WBS aged 0?67.1 years were compared with that in controls and also with available normative data. Association testing was used to identify relevant comorbidities. Results: On average, individuals with WBS had higher plasma calcium levels than controls, but 86.7% of values were normal. Nonpediatric laboratories overreport hypercalcemia in small children. When pediatric reference intervals were applied, the occurrence of hypercalcemia dropped by 51% in infants and by 38% in toddlers. Across all ages, 6.1% of the subjects had actionable hypercalcemia. In children, actionable hypercalcemia was seen in those aged 5?25 months. In older individuals, actionable hypercalcemia was often secondary to another disease process. Evidence of dehydration, hypercalciuria, and nephrocalcinosis were common in both groups. Future hypercalcemia could not be reliably predicted by screening calcium levels. A subgroup analysis of 91 subjects found no associations between hypercalcemia and cardiovascular disease, gastrointestinal complaints, or renal anomalies. Analyses of electrogradiography data showed an inverse correlation of calcium concentration with corrected QT interval, but no acute life-threatening events were reported. Conclusions: Actionable hypercalcemia in patients with WBS occurs infrequently. Although irritability and lethargy were commonly reported, no mortality or acute life-threatening events were associated with hypercalcemia and the only statistically associated morbidities were dehydration, hypercalciuria, and nephrocalcinosis. äHypercalcemia in Patients with Williams-Beuren Syndrome (epmc).pdf DeepDyve Pubget Overpricing