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10.3390/ijms17101649 http://scihub22266oqcxt.onion/10.3390/ijms17101649 C5085682!5085682!27690013     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2016 ; 17 (10): ä Nephropedia Template TP {{tp|p=27690013|t=2016. Time in Redox Adaptation Processes: From Evolution to Hormesis |pdf=|usr=}}{{27690013}} gab.com Text Time in Redox Adaptation Processes: From Evolution to Hormesis JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27690013 #FOAvip Life on Earth has to adapt to the ever changing environment. For example, due to introduction of oxygen in the atmosphere, an antioxidant network evolved to cope with the exposure to oxygen. The adaptive mechanisms of the antioxidant network, specifically the glutathione (GSH) system, are reviewed with a special focus on the time. The quickest adaptive response to oxidative stress is direct enzyme modification, increasing the GSH levels or activating the GSH-dependent protective enzymes. After several hours, a hormetic response is seen at the transcriptional level by up-regulating Nrf2-mediated expression of enzymes involved in GSH synthesis. In the long run, adaptations occur at the epigenetic and genomic level; for example, the ability to synthesize GSH by phototrophic bacteria. Apparently, in an adaptive hormetic response not only the dose or the compound, but also time, should be considered. This is essential for targeted interventions aimed to prevent diseases by successfully coping with changes in the environment e.g., oxidative stress. Twit Text FOAVip Time in Redox Adaptation Processes: From Evolution to Hormesis ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27690013 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27690013 #FOAvip English Wikipedia <ref>{{Cite pmid|27690013}}</ref> Time in Redox Adaptation Processes: From Evolution to Hormesis #MMPMID27690013 Sthijns MMJPE; Weseler AR; Bast A; Haenen GRMM Int J Mol Sci 2016[Oct]; 17 (10): ä PMID27690013show ga Life on Earth has to adapt to the ever changing environment. For example, due to introduction of oxygen in the atmosphere, an antioxidant network evolved to cope with the exposure to oxygen. The adaptive mechanisms of the antioxidant network, specifically the glutathione (GSH) system, are reviewed with a special focus on the time. The quickest adaptive response to oxidative stress is direct enzyme modification, increasing the GSH levels or activating the GSH-dependent protective enzymes. After several hours, a hormetic response is seen at the transcriptional level by up-regulating Nrf2-mediated expression of enzymes involved in GSH synthesis. In the long run, adaptations occur at the epigenetic and genomic level; for example, the ability to synthesize GSH by phototrophic bacteria. Apparently, in an adaptive hormetic response not only the dose or the compound, but also time, should be considered. This is essential for targeted interventions aimed to prevent diseases by successfully coping with changes in the environment e.g., oxidative stress. äTime in Redox Adaptation Processes: From Evolution to Hormesis (epmc).pdf DeepDyve Pubget Overpricing