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10.3390/ijms17101617 http://scihub22266oqcxt.onion/10.3390/ijms17101617 C5085650!5085650 !27669232     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27669232 &cmd=llinks): Failed to open stream: HTTP request failed! 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Long Noncoding RNA lncCAMTA1 Promotes Proliferation and Cancer Stem Cell-Like Properties of Liver Cancer by Inhibiting CAMTA1 |pdf=|usr=}}{{27669232 }} gab.com Text Long Noncoding RNA lncCAMTA1 Promotes Proliferation and Cancer Stem Cell-Like Properties of Liver Cancer by Inhibiting CAMTA1 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27669232 #FOAvip Hepatocellular carcinoma (HCC) is the most common subtype of liver malignancy, and it is characterized by poor prognosis because of cancer stem cell (CSC)-mediated high postsurgical recurrence rates. Thus, targeting CSCs, or HCC cells with CSC-like properties, is an effective strategy for HCC therapy. Here, using long noncoding RNA (lncRNA) microarray analysis, we identified a novel lncRNA termed lncCAMTA1 that is increased in both liver CSCs and HCC. High lncCAMTA1 expression in HCC indicates poor clinical outcome. In vitro and in vivo functional experiments showed that overexpression of lncCAMTA1 promotes HCC cell proliferation, CSC-like properties, and tumorigenesis. Conversely, depletion of lncCAMTA1 inhibits HCC cell proliferation, CSC-like properties, and tumorigenesis. Mechanistically, we demonstrated that lncCAMTA1 physically associates with the calmodulin binding transcription activator 1 (CAMTA1) promoter, induces a repressive chromatin structure, and inhibits CAMTA1 transcription. Furthermore, CAMTA1 is required for the effects of lncCAMTA1 on HCC cell proliferation and CSC-like properties, and the expression of lncCAMTA1 and CAMTA1 is significantly negatively correlated in HCC tissues. Collectively, our study revealed the important roles and underlying molecular mechanisms of lncCAMTA1 on HCC, and suggested that lncCAMTA1 could be an effective prognostic factor and a potential therapeutic target for HCC. Twit Text FOAVip Long Noncoding RNA lncCAMTA1 Promotes Proliferation and Cancer Stem Cell-Like Properties of Liver Cancer by Inhibiting CAMTA1 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27669232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27669232 #FOAvip English Wikipedia <ref>{{Cite pmid|27669232 }}</ref> Long Noncoding RNA lncCAMTA1 Promotes Proliferation and Cancer Stem Cell-Like Properties of Liver Cancer by Inhibiting CAMTA1 #MMPMID27669232 Ding LJ ; Li Y ; Wang SD ; Wang XS ; Fang F ; Wang WY ; Lv P ; Zhao DH ; Wei F ; Qi L Int J Mol Sci 2016[Sep]; 17 (10 ): ä PMID27669232 show ga Hepatocellular carcinoma (HCC) is the most common subtype of liver malignancy, and it is characterized by poor prognosis because of cancer stem cell (CSC)-mediated high postsurgical recurrence rates. Thus, targeting CSCs, or HCC cells with CSC-like properties, is an effective strategy for HCC therapy. Here, using long noncoding RNA (lncRNA) microarray analysis, we identified a novel lncRNA termed lncCAMTA1 that is increased in both liver CSCs and HCC. High lncCAMTA1 expression in HCC indicates poor clinical outcome. In vitro and in vivo functional experiments showed that overexpression of lncCAMTA1 promotes HCC cell proliferation, CSC-like properties, and tumorigenesis. Conversely, depletion of lncCAMTA1 inhibits HCC cell proliferation, CSC-like properties, and tumorigenesis. Mechanistically, we demonstrated that lncCAMTA1 physically associates with the calmodulin binding transcription activator 1 (CAMTA1) promoter, induces a repressive chromatin structure, and inhibits CAMTA1 transcription. Furthermore, CAMTA1 is required for the effects of lncCAMTA1 on HCC cell proliferation and CSC-like properties, and the expression of lncCAMTA1 and CAMTA1 is significantly negatively correlated in HCC tissues. Collectively, our study revealed the important roles and underlying molecular mechanisms of lncCAMTA1 on HCC, and suggested that lncCAMTA1 could be an effective prognostic factor and a potential therapeutic target for HCC. |Animals [MESH] |Calcium-Binding Proteins/antagonists & inhibitors/*genetics/metabolism [MESH] |Carcinoma, Hepatocellular/metabolism/mortality/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Chromatin/chemistry [MESH] |Databases, Factual [MESH] |Disease-Free Survival [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Liver Neoplasms/metabolism/mortality/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Neoplastic Stem Cells/cytology/metabolism [MESH] |Oligonucleotides, Antisense/metabolism [MESH] |Promoter Regions, Genetic [MESH] |RNA Interference [MESH] |RNA, Long Noncoding/antagonists & inhibitors/genetics/*metabolism [MESH] |RNA, Small Interfering/metabolism [MESH] |Trans-Activators/antagonists & inhibitors/*genetics/metabolism [MESH]Long Noncoding RNA lncCAMTA1 Promotes Proliferation and Cancer Stem Ce(epmc).pdf DeepDyve Pubget Overpricing