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10.1681/ASN.2015070827 http://scihub22266oqcxt.onion/10.1681/ASN.2015070827 C5084882!5084882 !26961349     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26961349 &cmd=llinks): Failed to open stream: HTTP request failed! 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Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties |pdf=|usr=}}{{26961349 }} gab.com Text Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26961349 #FOAvip Cisplatin is an effective anticancer drug; however, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. In this study, we determined the effect of dichloroacetate, a novel anticancer agent, in a mouse model of cisplatin-induced AKI. Pretreatment with dichloroacetate significantly attenuated the cisplatin-induced increase in BUN and serum creatinine levels, renal tubular apoptosis, and oxidative stress. Additionally, pretreatment with dichloroacetate accelerated tubular regeneration after cisplatin-induced renal damage. Whole transcriptome sequencing revealed that dichloroacetate prevented mitochondrial dysfunction and preserved the energy-generating capacity of the kidneys by preventing the cisplatin-induced downregulation of fatty acid and glucose oxidation, and of genes involved in the Krebs cycle and oxidative phosphorylation. Notably, dichloroacetate did not interfere with the anticancer activity of cisplatin in vivo. These data provide strong evidence that dichloroacetate preserves renal function when used in conjunction with cisplatin. Twit Text FOAVip Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26961349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26961349 #FOAvip English Wikipedia <ref>{{Cite pmid|26961349 }}</ref> Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties #MMPMID26961349 Galgamuwa R ; Hardy K ; Dahlstrom JE ; Blackburn AC ; Wium E ; Rooke M ; Cappello JY ; Tummala P ; Patel HR ; Chuah A ; Tian L ; McMorrow L ; Board PG ; Theodoratos A J Am Soc Nephrol 2016[Nov]; 27 (11 ): 3331-3344 PMID26961349 show ga Cisplatin is an effective anticancer drug; however, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. In this study, we determined the effect of dichloroacetate, a novel anticancer agent, in a mouse model of cisplatin-induced AKI. Pretreatment with dichloroacetate significantly attenuated the cisplatin-induced increase in BUN and serum creatinine levels, renal tubular apoptosis, and oxidative stress. Additionally, pretreatment with dichloroacetate accelerated tubular regeneration after cisplatin-induced renal damage. Whole transcriptome sequencing revealed that dichloroacetate prevented mitochondrial dysfunction and preserved the energy-generating capacity of the kidneys by preventing the cisplatin-induced downregulation of fatty acid and glucose oxidation, and of genes involved in the Krebs cycle and oxidative phosphorylation. Notably, dichloroacetate did not interfere with the anticancer activity of cisplatin in vivo. These data provide strong evidence that dichloroacetate preserves renal function when used in conjunction with cisplatin. |Animals [MESH] |Antineoplastic Agents/*adverse effects/therapeutic use [MESH] |Cisplatin/*adverse effects/therapeutic use [MESH] |Dichloroacetic Acid/*therapeutic use [MESH] |Female [MESH] |Kidney Diseases/*chemically induced/*prevention & control [MESH] |Male [MESH] |Mice [MESH]Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Comp(epmc).pdf DeepDyve Pubget Overpricing