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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Chest+Med 2016 ; 37 (2): 321-31 Nephropedia Template TP
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Metabolism, metabolomics, and nutritional support of patients with sepsis #MMPMID27229648
Englert JA; Rogers AJ
Clin Chest Med 2016[Jun]; 37 (2): 321-31 PMID27229648show ga
Sepsis is characterized by profound metabolic changes including both systemic and cellular alterations that lead to the disruption of normal metabolic homeostasis. These metabolic changes serve as biomarkers for disease severity. Lactate, a metabolite of anaerobic metabolism, is the most widely used ICU biomarker and its use is incorporated into multiple management algorithms. Technological advances now make broader metabolic profiling possible in sepsis, with early studies identifying several metabolic changes associated with sepsis mortality. Finally, given both the marked changes in metabolism in sepsis and the association of worse short- and long-term prognosis in patients with severe metabolic derangements, we summarize the seminal trials conducted to optimize nutrition in the ICU.