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10.1016/j.ccm.2016.01.011

http://scihub22266oqcxt.onion/10.1016/j.ccm.2016.01.011
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C5084839!5084839!27229648
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suck abstract from ncbi


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pmid27229648      Clin+Chest+Med 2016 ; 37 (2): 321-31
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  • Metabolism, metabolomics, and nutritional support of patients with sepsis #MMPMID27229648
  • Englert JA; Rogers AJ
  • Clin Chest Med 2016[Jun]; 37 (2): 321-31 PMID27229648show ga
  • Sepsis is characterized by profound metabolic changes including both systemic and cellular alterations that lead to the disruption of normal metabolic homeostasis. These metabolic changes serve as biomarkers for disease severity. Lactate, a metabolite of anaerobic metabolism, is the most widely used ICU biomarker and its use is incorporated into multiple management algorithms. Technological advances now make broader metabolic profiling possible in sepsis, with early studies identifying several metabolic changes associated with sepsis mortality. Finally, given both the marked changes in metabolism in sepsis and the association of worse short- and long-term prognosis in patients with severe metabolic derangements, we summarize the seminal trials conducted to optimize nutrition in the ICU.
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