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10.1002/ejhf.548 http://scihub22266oqcxt.onion/10.1002/ejhf.548 C5084812!5084812!27170530     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27170530.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Heart+Fail 2016 ; 18 (9): 1193-202 Nephropedia Template TP {{tp|p=27170530|t=2016. Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double?blind, randomized comparison of two uptitration regimens |pdf=|usr=}}{{27170530}} gab.com Text Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double blind, randomized comparison of two uptitration regimens JO: Eur J Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=27170530 #FOAvip Aims: To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ?35%). Methods and results: A 5?day open?label run?in (sacubitril/valsartan 50 mg twice daily) preceded an 11?week, double?blind, randomization period [100 mg twice daily for 2 weeks followed by 200 mg twice daily (?condensed? regimen) vs. 50 mg twice daily for 2 weeks, 100 mg twice daily for 3 weeks, followed by 200 mg twice daily (?conservative? regimen)]. Patients were stratified by pre?study dose of angiotensin?converting enzyme inhibitor/angiotensin?receptor blocker (ACEI/ARB; low?dose stratum included ACEI/ARB?naďve patients). Of 540 patients entering run?in, 498 (92%) were randomized and 429 (86.1% of randomized) completed the study. Pre?defined tolerability criteria were hypotension, renal dysfunction and hyperkalaemia; and adjudicated angioedema, which occurred in (?condensed? vs. ?conservative?) 9.7% vs. 8.4% (P = 0.570), 7.3% vs. 7.6% (P = 0.990), 7.7% vs. 4.4% (P = 0.114), and 0.0% vs. 0.8% of patients, respectively. Corresponding proportions for pre?defined systolic blood pressure <95 mmHg, serum potassium >5.5 mmol/L, and serum creatinine >3.0 mg/dL were 8.9% vs. 5.2% (P = 0.102), 7.3% vs. 4.0% (P = 0.097), and 0.4% vs. 0%, respectively. In total, 378 (76%) patients achieved and maintained sacubitril/valsartan 200 mg twice daily without dose interruption/down?titration over 12 weeks (77.8% vs. 84.3% for ?condensed? vs. ?conservative?; P = 0.078). Rates by ACEI/ARB pre?study dose stratification were 82.6% vs. 83.8% (P = 0.783) for high?dose/?condensed? vs. high?dose/?conservative? and 84.9% vs. 73.6% (P = 0.030) for low?dose/?conservative? vs. low?dose/?condensed?. Conclusions: Initiation/uptitration of sacubitril/valsartan from 50 to 200 mg twice daily over 3 or 6 weeks had a tolerability profile in line with other HF treatments. More gradual initiation/uptitration maximized attainment of target dose in the low?dose ACEI/ARB group. Twit Text FOAVip Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double blind, randomized comparison of two uptitration regimens ????Eur J Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=27170530 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27170530 #FOAvip English Wikipedia <ref>{{Cite pmid|27170530}}</ref> Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double?blind, randomized comparison of two uptitration regimens #MMPMID27170530 Senni M; McMurray JJ; Wachter R; McIntyre HF; Reyes A; Majercak I; Andreka P; Shehova?Yankova N; Anand I; Yilmaz MB; Gogia H; Martinez?Selles M; Fischer S; Zilahi Z; Cosmi F; Gelev V; Galve E; Gómez?Doblas JJ; Nociar J; Radomska M; Sokolova B; Volterrani M; Sarkar A; Reimund B; Chen F; Charney A Eur J Heart Fail 2016[Sep]; 18 (9): 1193-202 PMID27170530show ga Aims: To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ?35%). Methods and results: A 5?day open?label run?in (sacubitril/valsartan 50 mg twice daily) preceded an 11?week, double?blind, randomization period [100 mg twice daily for 2 weeks followed by 200 mg twice daily (?condensed? regimen) vs. 50 mg twice daily for 2 weeks, 100 mg twice daily for 3 weeks, followed by 200 mg twice daily (?conservative? regimen)]. Patients were stratified by pre?study dose of angiotensin?converting enzyme inhibitor/angiotensin?receptor blocker (ACEI/ARB; low?dose stratum included ACEI/ARB?naďve patients). Of 540 patients entering run?in, 498 (92%) were randomized and 429 (86.1% of randomized) completed the study. Pre?defined tolerability criteria were hypotension, renal dysfunction and hyperkalaemia; and adjudicated angioedema, which occurred in (?condensed? vs. ?conservative?) 9.7% vs. 8.4% (P = 0.570), 7.3% vs. 7.6% (P = 0.990), 7.7% vs. 4.4% (P = 0.114), and 0.0% vs. 0.8% of patients, respectively. Corresponding proportions for pre?defined systolic blood pressure <95 mmHg, serum potassium >5.5 mmol/L, and serum creatinine >3.0 mg/dL were 8.9% vs. 5.2% (P = 0.102), 7.3% vs. 4.0% (P = 0.097), and 0.4% vs. 0%, respectively. In total, 378 (76%) patients achieved and maintained sacubitril/valsartan 200 mg twice daily without dose interruption/down?titration over 12 weeks (77.8% vs. 84.3% for ?condensed? vs. ?conservative?; P = 0.078). Rates by ACEI/ARB pre?study dose stratification were 82.6% vs. 83.8% (P = 0.783) for high?dose/?condensed? vs. high?dose/?conservative? and 84.9% vs. 73.6% (P = 0.030) for low?dose/?conservative? vs. low?dose/?condensed?. Conclusions: Initiation/uptitration of sacubitril/valsartan from 50 to 200 mg twice daily over 3 or 6 weeks had a tolerability profile in line with other HF treatments. More gradual initiation/uptitration maximized attainment of target dose in the low?dose ACEI/ARB group. äInitiating sacubitril/valsartan (LCZ696) in heart failure: results of (epmc).pdf DeepDyve Pubget Overpricing