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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 FEBS+Lett 2016 ; 590 (9): 1291-303 Nephropedia Template TP
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WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway #MMPMID27098453
Goto T; Matsuzawa J; Iemura S; Natsume T; Shibuya H
FEBS Lett 2016[May]; 590 (9): 1291-303 PMID27098453show ga
The stability of ??catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3? phosphorylates ??catenin to be degraded by ubiquitination with ??TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative regulator of the canonical Wnt signaling pathway, and that WDR26 affected ??catenin levels. In addition, WDR26/Axin binding is involved in the ubiquitination of ??catenin. These results suggest that WDR26 plays a negative role in ??catenin degradation in the Wnt signaling pathway.