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10.1002/1873-3468.12180

http://scihub22266oqcxt.onion/10.1002/1873-3468.12180
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C5084729!5084729!27098453
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suck abstract from ncbi


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pmid27098453      FEBS+Lett 2016 ; 590 (9): 1291-303
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  • WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway #MMPMID27098453
  • Goto T; Matsuzawa J; Iemura S; Natsume T; Shibuya H
  • FEBS Lett 2016[May]; 590 (9): 1291-303 PMID27098453show ga
  • The stability of ??catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3? phosphorylates ??catenin to be degraded by ubiquitination with ??TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative regulator of the canonical Wnt signaling pathway, and that WDR26 affected ??catenin levels. In addition, WDR26/Axin binding is involved in the ubiquitination of ??catenin. These results suggest that WDR26 plays a negative role in ??catenin degradation in the Wnt signaling pathway.
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