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10.1083/jcb.201601083

http://scihub22266oqcxt.onion/10.1083/jcb.201601083
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C5084644!5084644!27810909
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suck abstract from ncbi


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pmid27810909      J+Cell+Biol 2016 ; 215 (2): 151-66
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  • The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage #MMPMID27810909
  • Balachandran RS; Heighington CS; Starostina NG; Anderson JW; Owen DL; Vasudevan S; Kipreos ET
  • J Cell Biol 2016[Oct]; 215 (2): 151-66 PMID27810909show ga
  • Cells arrested in mitosis by inactivation of the APC/C complex sometimes manage to exit mitosis in a process called mitotic slippage, which helps cancer cells circumvent chemotherapy drugs. Balachandran et al. show that mitotic slippage occurs as a result of targeting of cyclin B1 for degradation by the ligase CRL2ZYG11.
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