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10.1083/jcb.201601083 http://scihub22266oqcxt.onion/10.1083/jcb.201601083 C5084644!5084644 !27810909     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27810909 &cmd=llinks): Failed to open stream: HTTP request failed! 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The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage |pdf=|usr=}}{{27810909 }} gab.com Text The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27810909 #FOAvip The anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase is known to target the degradation of cyclin B1, which is crucial for mitotic progression in animal cells. In this study, we show that the ubiquitin ligase CRL2(ZYG-11) redundantly targets the degradation of cyclin B1 in Caenorhabditis elegans and human cells. In C. elegans, both CRL2(ZYG-11) and APC/C are required for proper progression through meiotic divisions. In human cells, inactivation of CRL2(ZYG11A/B) has minimal effects on mitotic progression when APC/C is active. However, when APC/C is inactivated or cyclin B1 is overexpressed, CRL2(ZYG11A/B)-mediated degradation of cyclin B1 is required for normal progression through metaphase. Mitotic cells arrested by the spindle assembly checkpoint, which inactivates APC/C, often exit mitosis in a process termed "mitotic slippage," which generates tetraploid cells and limits the effectiveness of antimitotic chemotherapy drugs. We show that ZYG11A/B subunit knockdown, or broad cullin-RING ubiquitin ligase inactivation with the small molecule MLN4924, inhibits mitotic slippage in human cells, suggesting the potential for antimitotic combination therapy. Twit Text FOAVip The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27810909 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27810909 #FOAvip English Wikipedia <ref>{{Cite pmid|27810909 }}</ref> The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage #MMPMID27810909 Balachandran RS ; Heighington CS ; Starostina NG ; Anderson JW ; Owen DL ; Vasudevan S ; Kipreos ET J Cell Biol 2016[Oct]; 215 (2 ): 151-166 PMID27810909 show ga The anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase is known to target the degradation of cyclin B1, which is crucial for mitotic progression in animal cells. In this study, we show that the ubiquitin ligase CRL2(ZYG-11) redundantly targets the degradation of cyclin B1 in Caenorhabditis elegans and human cells. In C. elegans, both CRL2(ZYG-11) and APC/C are required for proper progression through meiotic divisions. In human cells, inactivation of CRL2(ZYG11A/B) has minimal effects on mitotic progression when APC/C is active. However, when APC/C is inactivated or cyclin B1 is overexpressed, CRL2(ZYG11A/B)-mediated degradation of cyclin B1 is required for normal progression through metaphase. Mitotic cells arrested by the spindle assembly checkpoint, which inactivates APC/C, often exit mitosis in a process termed "mitotic slippage," which generates tetraploid cells and limits the effectiveness of antimitotic chemotherapy drugs. We show that ZYG11A/B subunit knockdown, or broad cullin-RING ubiquitin ligase inactivation with the small molecule MLN4924, inhibits mitotic slippage in human cells, suggesting the potential for antimitotic combination therapy. |*Mitosis/drug effects [MESH] |*Proteolysis/drug effects [MESH] |Anaphase-Promoting Complex-Cyclosome/metabolism [MESH] |Animals [MESH] |CDC2 Protein Kinase/metabolism [MESH] |Caenorhabditis elegans Proteins/*metabolism [MESH] |Caenorhabditis elegans/*cytology/drug effects/*metabolism [MESH] |Cell Cycle Proteins/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cyclin B1/*metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Nocodazole/pharmacology [MESH] |Protein Binding/drug effects [MESH] |Substrate Specificity/drug effects [MESH]The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a (epmc).pdf DeepDyve Pubget Overpricing