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10.1097/TP.0000000000001333

http://scihub22266oqcxt.onion/10.1097/TP.0000000000001333
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C5084638!5084638!27391196
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suck abstract from ncbi


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pmid27391196      Transplantation 2016 ; 100 (11): 2276-87
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  • BK Polyomavirus and the Transplanted Kidney: Immunopathology and Therapeutic Approaches #MMPMID27391196
  • Lamarche C; Orio J; Collette S; Senécal L; Hébert MJ; Renoult É; Tibbles LA; Delisle JS
  • Transplantation 2016[Nov]; 100 (11): 2276-87 PMID27391196show ga
  • BK polyomavirus is ubiquitous, with a seropositivity rate of over 75% in the adult population. Primary infection is thought to occur in the respiratory tract, but asymptomatic BK virus latency is established in the urothelium. In immunocompromised host, the virus can reactivate but rarely compromises kidney function except in renal grafts, where it causes a tubulointerstitial inflammatory response similar to acute rejection. Restoring host immunity against the virus is the cornerstone of treatment. This review covers the virus-intrinsic features, the posttransplant microenvironment as well as the host immune factors that underlie the pathophysiology of polyomavirus-associated nephropathy. Current and promising therapeutic approaches to treat or prevent this complication are discussed in relation to the complex immunopathology of this condition.
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