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10.3390/genes7100071 http://scihub22266oqcxt.onion/10.3390/genes7100071 C5083910!5083910!27669308     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2016 ; 7 (10): ä Nephropedia Template TP {{tp|p=27669308|t=2016. Making Sense of the Tangle: Insights into Chromatin Folding and Gene Regulation |pdf=|usr=}}{{27669308}} gab.com Text Making Sense of the Tangle: Insights into Chromatin Folding and Gene Regulation JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27669308 #FOAvip Proximity ligation assays such as circularized chromosome conformation capture and high-throughput chromosome capture assays have shed light on the structural organization of the interphase genome. Functional topologically associating domains (TADs) that constitute the building blocks of genomic organization are disrupted and reconstructed during the cell cycle. Epigenetic memory, as well as the sequence of chromosomes, regulate TAD reconstitution. Sub-TAD domains that are invariant across cell types have been identified, and contacts between these domains, rather than looping, are speculated to drive chromatin folding. Replication domains are established simultaneously with TADs during the cell cycle and the two correlate well in terms of characteristic features, such as lamin association and histone modifications. CCCTC-binding factor (CTCF) and cohesin cooperate across different cell types to regulate genes and genome organization. CTCF elements that demarcate TAD boundaries are commonly disrupted in cancer and promote oncogene activation. Chromatin looping facilitates interactions between distant promoters and enhancers, and the resulting enhanceosome complex promotes gene expression. Deciphering the chromatin tangle requires comprehensive integrative analyses of DNA- and protein-dependent factors that regulate genomic organization. Twit Text FOAVip Making Sense of the Tangle: Insights into Chromatin Folding and Gene Regulation ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27669308 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27669308 #FOAvip English Wikipedia <ref>{{Cite pmid|27669308}}</ref> Making Sense of the Tangle: Insights into Chromatin Folding and Gene Regulation #MMPMID27669308 Chung IM; Ketharnathan S; Kim SH; Thiruvengadam M; Rani MK; Rajakumar G Genes (Basel) 2016[Oct]; 7 (10): ä PMID27669308show ga Proximity ligation assays such as circularized chromosome conformation capture and high-throughput chromosome capture assays have shed light on the structural organization of the interphase genome. Functional topologically associating domains (TADs) that constitute the building blocks of genomic organization are disrupted and reconstructed during the cell cycle. Epigenetic memory, as well as the sequence of chromosomes, regulate TAD reconstitution. Sub-TAD domains that are invariant across cell types have been identified, and contacts between these domains, rather than looping, are speculated to drive chromatin folding. Replication domains are established simultaneously with TADs during the cell cycle and the two correlate well in terms of characteristic features, such as lamin association and histone modifications. CCCTC-binding factor (CTCF) and cohesin cooperate across different cell types to regulate genes and genome organization. CTCF elements that demarcate TAD boundaries are commonly disrupted in cancer and promote oncogene activation. Chromatin looping facilitates interactions between distant promoters and enhancers, and the resulting enhanceosome complex promotes gene expression. Deciphering the chromatin tangle requires comprehensive integrative analyses of DNA- and protein-dependent factors that regulate genomic organization. äMaking Sense of the Tangle: Insights into Chromatin Folding and Gene R(epmc).pdf DeepDyve Pubget Overpricing