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10.1021/acschembio.5b00806 http://scihub22266oqcxt.onion/10.1021/acschembio.5b00806 C5082698!5082698!26741163     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Biol 2016 ; 11 (4): 992-1000 Nephropedia Template TP {{tp|p=26741163|t=2016. Stable Colloidal Drug Aggregates Catch and Release Active Enzymes |pdf=|usr=}}{{26741163}} gab.com Text Stable Colloidal Drug Aggregates Catch and Release Active Enzymes JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26741163 #FOAvip Small molecule aggregates are considered nuisance compounds in drug discovery, but their unusual properties as colloids could be exploited to form stable vehicles to preserve protein activity. We investigated the co-aggregation of seven molecules chosen because they had been previously intensely studied as colloidal aggregators, co-formulating them with bis-azo dyes. The co-formulation reduced colloid sizes to <100 nm, and improved uniformity of the particle size distribution. The new colloid formulations are more stable than previous aggregator particles. Specifically, co-aggregation of Congo Red with sorafenib, tetraiodophenolphthalein (TIPT) or vemurafenib produced particles that are stable in solutions of high ionic strength and high protein concentrations. Like traditional, single compound colloidal aggregates, the stabilized colloids adsorbed and inhibited enzymes like ?-lactamase, malate dehydrogenase and trypsin. Unlike traditional aggregates, the co-formulated colloid-protein particles could be centrifuged and re-suspended multiple times, and from re-suspended particles, active trypsin could be released up to 72 hours after adsorption. Unexpectedly, the stable colloidal formulations can sequester, stabilize, and isolate enzymes by spin-down, resuspension and release. Twit Text FOAVip Stable Colloidal Drug Aggregates Catch and Release Active Enzymes ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26741163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26741163 #FOAvip English Wikipedia <ref>{{Cite pmid|26741163}}</ref> Stable Colloidal Drug Aggregates Catch and Release Active Enzymes #MMPMID26741163 McLaughlin CK; Duan D; Ganesh AN; Torosyan H; Shoichet BK; Shoichet MS ACS Chem Biol 2016[Apr]; 11 (4): 992-1000 PMID26741163show ga Small molecule aggregates are considered nuisance compounds in drug discovery, but their unusual properties as colloids could be exploited to form stable vehicles to preserve protein activity. We investigated the co-aggregation of seven molecules chosen because they had been previously intensely studied as colloidal aggregators, co-formulating them with bis-azo dyes. The co-formulation reduced colloid sizes to <100 nm, and improved uniformity of the particle size distribution. The new colloid formulations are more stable than previous aggregator particles. Specifically, co-aggregation of Congo Red with sorafenib, tetraiodophenolphthalein (TIPT) or vemurafenib produced particles that are stable in solutions of high ionic strength and high protein concentrations. Like traditional, single compound colloidal aggregates, the stabilized colloids adsorbed and inhibited enzymes like ?-lactamase, malate dehydrogenase and trypsin. Unlike traditional aggregates, the co-formulated colloid-protein particles could be centrifuged and re-suspended multiple times, and from re-suspended particles, active trypsin could be released up to 72 hours after adsorption. Unexpectedly, the stable colloidal formulations can sequester, stabilize, and isolate enzymes by spin-down, resuspension and release. äStable Colloidal Drug Aggregates Catch and Release Active Enzymes (epmc).pdf DeepDyve Pubget Overpricing