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10.1073/pnas.1605543113 http://scihub22266oqcxt.onion/10.1073/pnas.1605543113 C5081657!5081657!27698124     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (42): E6427-36 Nephropedia Template TP {{tp|p=27698124|t=2016. Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination |pdf=|usr=}}{{27698124}} gab.com Text Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27698124 #FOAvip Immunoglobulin and T-cell receptor genes are assembled in lymphoid cells from gene fragments by the process known as V(D)J recombination, which is initiated by the recombination activating gene (RAG)1/RAG2 recombinase. To ensure that recombination occurs only in the correct cell type and at the right developmental stage, multiple layers of regulation are necessary, including specific modifications of chromatin. We show that nucleosome positioning is another important factor in this regulation. Developmentally regulated changes in nucleosome positioning help to guide RAG1/RAG2 to the correct sites in recombinationally active cells. These changes occur on the scale of hundreds of kilobases, a form of regulation not typically seen in the rest of the mammalian genome. Twit Text FOAVip Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27698124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27698124 #FOAvip English Wikipedia <ref>{{Cite pmid|27698124}}</ref> Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination #MMPMID27698124 Pulivarthy SR; Lion M; Kuzu G; Matthews AGW; Borowsky ML; Morris J; Kingston RE; Dennis JH; Tolstorukov MY; Oettinger MA Proc Natl Acad Sci U S A 2016[Oct]; 113 (42): E6427-36 PMID27698124show ga Immunoglobulin and T-cell receptor genes are assembled in lymphoid cells from gene fragments by the process known as V(D)J recombination, which is initiated by the recombination activating gene (RAG)1/RAG2 recombinase. To ensure that recombination occurs only in the correct cell type and at the right developmental stage, multiple layers of regulation are necessary, including specific modifications of chromatin. We show that nucleosome positioning is another important factor in this regulation. Developmentally regulated changes in nucleosome positioning help to guide RAG1/RAG2 to the correct sites in recombinationally active cells. These changes occur on the scale of hundreds of kilobases, a form of regulation not typically seen in the rest of the mammalian genome. äRegulated large-scale nucleosome density patterns and precise nucleoso(epmc).pdf DeepDyve Pubget Overpricing