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10.1073/pnas.1610177113 http://scihub22266oqcxt.onion/10.1073/pnas.1610177113 C5081628!5081628!27708162     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (42): E6476-85 Nephropedia Template TP {{tp|p=27708162|t=2016. The Architecture of Trypanosoma brucei editosomes |pdf=|usr=}}{{27708162}} gab.com Text The Architecture of Trypanosoma brucei editosomes JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27708162 #FOAvip Trypanosoma brucei is a deadly kinetoplastid parasite that causes the human and veterinarian diseases African sleeping sickness and nagana. We combine chemical cross-linking and mass spectrometry, structural modeling, genetics, and biochemistry to define the global architecture of RNA editing ?editosome? complexes in these parasites. Editosomes are unique to kinetoplastids, which also include Trypanosoma cruzi and Leishmania parasites that cause Chagas disease and Leishmaniases, respectively. Editosomes are essential for parasite viability and are promising drug targets. This work creates a comprehensive, highly detailed map of editosome protein proximities and interactions, and furthers our understanding of editosome protein function in T. brucei and other kinetoplastids, thus aiding the potential development of new therapeutics for the treatment of several different parasitic diseases. Twit Text FOAVip The Architecture of Trypanosoma brucei editosomes ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27708162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27708162 #FOAvip English Wikipedia <ref>{{Cite pmid|27708162}}</ref> The Architecture of Trypanosoma brucei editosomes #MMPMID27708162 McDermott SM; Luo J; Carnes J; Ranish JA; Stuart K Proc Natl Acad Sci U S A 2016[Oct]; 113 (42): E6476-85 PMID27708162show ga Trypanosoma brucei is a deadly kinetoplastid parasite that causes the human and veterinarian diseases African sleeping sickness and nagana. We combine chemical cross-linking and mass spectrometry, structural modeling, genetics, and biochemistry to define the global architecture of RNA editing ?editosome? complexes in these parasites. Editosomes are unique to kinetoplastids, which also include Trypanosoma cruzi and Leishmania parasites that cause Chagas disease and Leishmaniases, respectively. Editosomes are essential for parasite viability and are promising drug targets. This work creates a comprehensive, highly detailed map of editosome protein proximities and interactions, and furthers our understanding of editosome protein function in T. brucei and other kinetoplastids, thus aiding the potential development of new therapeutics for the treatment of several different parasitic diseases. äThe Architecture of Trypanosoma brucei editosomes (epmc).pdf DeepDyve Pubget Overpricing