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10.3389/fimmu.2016.00460

http://scihub22266oqcxt.onion/10.3389/fimmu.2016.00460
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C5081350!5081350!27833613
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suck abstract from ncbi


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pmid27833613      Front+Immunol 2016 ; 7 (ä): ä
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  • Modulation of Inflammatory Responses by Wnt/?-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer #MMPMID27833613
  • Suryawanshi A; Tadagavadi RK; Swafford D; Manicassamy S
  • Front Immunol 2016[]; 7 (ä): ä PMID27833613show ga
  • The Wnt/?-catenin pathway is an evolutionarily conserved signaling pathway critical for several biological processes. An aberrant Wnt/?-catenin signaling is linked to several human diseases. Emerging studies have highlighted the regulatory role of the Wnt/?-catenin signaling pathway in normal physiological processes of parenchymal and hematopoietic cells. Recent studies have shown that the activation of Wnt/?-catenin pathway in dendritic cells (DCs) play a critical role in mucosal tolerance and suppression of chronic autoimmune pathologies. Alternatively, tumors activate Wnt/?-catenin pathway in DCs to induce immune tolerance and thereby evade antitumor immunity through suppression of effector T cell responses and promotion of regulatory T cell responses. Here, we review our work and current understanding of how Wnt/?-catenin signaling in DCs shapes the immune response in cancer and autoimmunity and discuss how Wnt/?-catenin pathway can be targeted for successful therapeutic interventions in various human diseases.
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