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2016 ; 48
(4
): 1443-1447
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Severe Hepatic Sinusoidal Obstruction Syndrome in a Child Receiving Vincristine,
Actinomycin-D, and Cyclophosphamide for Rhabdomyosarcoma: Successful Treatment
with Defibrotide
#MMPMID27034141
Choi A
; Kang YK
; Lim S
; Kim DH
; Lim JS
; Lee JA
Cancer Res Treat
2016[Oct]; 48
(4
): 1443-1447
PMID27034141
show ga
Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening syndrome that
generally occurs as a complication after hematopoietic stem cell transplantation
or, less commonly, after conventional chemotherapy. Regarding SOS in
rhabdomyosarcoma patients who received conventional chemotherapy, the doses of
chemotherapeutic agents are associated with the development of SOS. Several cases
of SOS in rhabdomyosarcoma patients after receiving chemotherapy with escalated
doses of cyclophosphamide have been reported. Here, we report on a 9-year-old
female with rhabdomyosarcoma who developed severe SOS after receiving
chemotherapy consisting of vincristine, actinomycin-D, and a moderate dose of
cyclophosphamide. She was treated successfully with defibrotide without sequelae
to the liver.