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10.4143/crt.2016.096

http://scihub22266oqcxt.onion/10.4143/crt.2016.096
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suck abstract from ncbi


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pmid27034141
      Cancer+Res+Treat 2016 ; 48 (4 ): 1443-1447
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  • Severe Hepatic Sinusoidal Obstruction Syndrome in a Child Receiving Vincristine, Actinomycin-D, and Cyclophosphamide for Rhabdomyosarcoma: Successful Treatment with Defibrotide #MMPMID27034141
  • Choi A ; Kang YK ; Lim S ; Kim DH ; Lim JS ; Lee JA
  • Cancer Res Treat 2016[Oct]; 48 (4 ): 1443-1447 PMID27034141 show ga
  • Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening syndrome that generally occurs as a complication after hematopoietic stem cell transplantation or, less commonly, after conventional chemotherapy. Regarding SOS in rhabdomyosarcoma patients who received conventional chemotherapy, the doses of chemotherapeutic agents are associated with the development of SOS. Several cases of SOS in rhabdomyosarcoma patients after receiving chemotherapy with escalated doses of cyclophosphamide have been reported. Here, we report on a 9-year-old female with rhabdomyosarcoma who developed severe SOS after receiving chemotherapy consisting of vincristine, actinomycin-D, and a moderate dose of cyclophosphamide. She was treated successfully with defibrotide without sequelae to the liver.
  • |Child [MESH]
  • |Cyclophosphamide/adverse effects [MESH]
  • |Dactinomycin/adverse effects [MESH]
  • |Female [MESH]
  • |Hepatic Veno-Occlusive Disease/chemically induced/*drug therapy/physiopathology [MESH]
  • |Humans [MESH]
  • |Liver/drug effects/pathology [MESH]
  • |Polydeoxyribonucleotides/*administration & dosage [MESH]
  • |Rhabdomyosarcoma/complications/*drug therapy/physiopathology [MESH]


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