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10.2337/db16-0298 http://scihub22266oqcxt.onion/10.2337/db16-0298 C5079639!5079639!27507854     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes 2016 ; 65 (11): 3369-83 Nephropedia Template TP {{tp|p=27507854|t=2016. CREBH Couples Circadian Clock With Hepatic Lipid Metabolism |pdf=|usr=}}{{27507854}} gab.com Text CREBH Couples Circadian Clock With Hepatic Lipid Metabolism JO: Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=27507854 #FOAvip The circadian clock orchestrates diverse physiological processes critical for health and disease. CREB, hepatocyte specific (CREBH) is a liver-enriched, endoplasmic reticulum (ER)?tethered transcription factor known to regulate the hepatic acute phase response and energy homeostasis under stress conditions. We demonstrate that CREBH is regulated by the circadian clock and functions as a circadian regulator of hepatic lipid metabolism. Proteolytic activation of CREBH in the liver exhibits typical circadian rhythmicity controlled by the core clock oscillator BMAL1 and AKT/glycogen synthase kinase 3? (GSK3?) signaling pathway. GSK3?-mediated phosphorylation of CREBH modulates the association between CREBH and the coat protein complex II transport vesicle and thus controls the ER-to-Golgi transport and subsequent proteolytic cleavage of CREBH in a circadian manner. Functionally, CREBH regulates circadian expression of the key genes involved in triglyceride (TG) and fatty acid (FA) metabolism and is required to maintain circadian amplitudes of blood TG and FA in mice. During the circadian cycle, CREBH rhythmically regulates and interacts with the hepatic nuclear receptors peroxisome proliferator?activated receptor ? and liver X receptor ? as well as with the circadian oscillation activator DBP and the repressor E4BP4 to modulate CREBH transcriptional activities. In conclusion, these studies reveal that CREBH functions as a circadian-regulated liver transcriptional regulator that integrates energy metabolism with circadian rhythm. Twit Text FOAVip CREBH Couples Circadian Clock With Hepatic Lipid Metabolism ????Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=27507854 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27507854 #FOAvip English Wikipedia <ref>{{Cite pmid|27507854}}</ref> CREBH Couples Circadian Clock With Hepatic Lipid Metabolism #MMPMID27507854 Zheng Z; Kim H; Qiu Y; Chen X; Mendez R; Dandekar A; Zhang X; Zhang C; Liu AC; Yin L; Lin JD; Walker PD; Kapatos G; Zhang K Diabetes 2016[Nov]; 65 (11): 3369-83 PMID27507854show ga The circadian clock orchestrates diverse physiological processes critical for health and disease. CREB, hepatocyte specific (CREBH) is a liver-enriched, endoplasmic reticulum (ER)?tethered transcription factor known to regulate the hepatic acute phase response and energy homeostasis under stress conditions. We demonstrate that CREBH is regulated by the circadian clock and functions as a circadian regulator of hepatic lipid metabolism. Proteolytic activation of CREBH in the liver exhibits typical circadian rhythmicity controlled by the core clock oscillator BMAL1 and AKT/glycogen synthase kinase 3? (GSK3?) signaling pathway. GSK3?-mediated phosphorylation of CREBH modulates the association between CREBH and the coat protein complex II transport vesicle and thus controls the ER-to-Golgi transport and subsequent proteolytic cleavage of CREBH in a circadian manner. Functionally, CREBH regulates circadian expression of the key genes involved in triglyceride (TG) and fatty acid (FA) metabolism and is required to maintain circadian amplitudes of blood TG and FA in mice. During the circadian cycle, CREBH rhythmically regulates and interacts with the hepatic nuclear receptors peroxisome proliferator?activated receptor ? and liver X receptor ? as well as with the circadian oscillation activator DBP and the repressor E4BP4 to modulate CREBH transcriptional activities. In conclusion, these studies reveal that CREBH functions as a circadian-regulated liver transcriptional regulator that integrates energy metabolism with circadian rhythm. äCREBH Couples Circadian Clock With Hepatic Lipid Metabolism (epmc).pdf DeepDyve Pubget Overpricing