Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27790386
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Intravital
2016 ; 5
(2
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Validation of a device for the active manipulation of the tumor microenvironment
during intravital imaging
#MMPMID27790386
Williams JK
; Entenberg D
; Wang Y
; Avivar-Valderas A
; Padgen M
; Clark A
; Aguirre-Ghiso JA
; Castracane J
; Condeelis JS
Intravital
2016[]; 5
(2
): ä PMID27790386
show ga
The tumor microenvironment is recognized as playing a significant role in the
behavior of tumor cells and their progression to metastasis. However, tools to
manipulate the tumor microenvironment directly, and image the consequences of
this manipulation with single cell resolution in real time in vivo, are lacking.
We describe here a method for the direct, local manipulation of
microenvironmental parameters through the use of an implantable Induction Nano
Intravital Device (iNANIVID) and simultaneous in vivo visualization of the
results at single-cell resolution. As a proof of concept, we deliver both a
sustained dose of EGF to tumor cells while intravital imaging their chemotactic
response as well as locally induce hypoxia in defined microenvironments in solid
tumors.