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10.3389/fphar.2016.00389 http://scihub22266oqcxt.onion/10.3389/fphar.2016.00389 C5078904!5078904 !27826242     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27826242 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Pharmacol 2016 ; 7 (ä): 389 Nephropedia Template TP {{tp|p=27826242 |t=2016. Fluoxetine Prevents A?(1-42)-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-?1 |pdf=|usr=}}{{27826242 }} gab.com Text Fluoxetine Prevents A (1-42)-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor- 1 JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27826242 #FOAvip Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating Transforming-Growth-Factor-?1 (TGF-?1) levels in depressed patients, and are currently studied for their neuroprotective properties in Alzheimer's disease. TGF-?1 is an anti-inflammatory cytokine that exerts neuroprotective effects against ?-amyloid (A?)-induced neurodegeneration. In the present work, the SSRI, fluoxetine, was tested for the ability to protect cortical neurons against 1 ?M oligomeric A?(1-42)-induced toxicity. At therapeutic concentrations (100 nM-1 ?M), fluoxetine significantly prevented A?-induced toxicity in mixed glia-neuronal cultures, but not in pure neuronal cultures. Though to a lesser extent, also sertraline was neuroprotective in mixed cultures, whereas serotonin (10 nM-10 ?M) did not mimick fluoxetine effects. Glia-conditioned medium collected from astrocytes challenged with fluoxetine protected pure cortical neurons against A? toxicity. The effect was lost in the presence of a neutralizing antibody against TGF-?1 in the conditioned medium, or when the specific inhibitor of type-1 TGF-?1 receptor, SB431542, was added to pure neuronal cultures. Accordingly, a 24 h treatment of cortical astrocytes with fluoxetine promoted the release of active TGF-?1 in the culture media through the conversion of latent TGF-?1 to mature TGF-?1. Unlike fluoxetine, both serotonin and sertraline did not stimulate the astrocyte release of active TGF-?1. We conclude that fluoxetine is neuroprotective against A? toxicity via a paracrine signaling mediated by TGF-?1, which does not result from a simplistic SERT blockade. Twit Text FOAVip Fluoxetine Prevents A (1-42)-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor- 1 ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27826242 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27826242 #FOAvip English Wikipedia <ref>{{Cite pmid|27826242 }}</ref> Fluoxetine Prevents A?(1-42)-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-?1 #MMPMID27826242 Caraci F ; Tascedda F ; Merlo S ; Benatti C ; Spampinato SF ; Munafò A ; Leggio GM ; Nicoletti F ; Brunello N ; Drago F ; Sortino MA ; Copani A Front Pharmacol 2016[]; 7 (ä): 389 PMID27826242 show ga Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating Transforming-Growth-Factor-?1 (TGF-?1) levels in depressed patients, and are currently studied for their neuroprotective properties in Alzheimer's disease. TGF-?1 is an anti-inflammatory cytokine that exerts neuroprotective effects against ?-amyloid (A?)-induced neurodegeneration. In the present work, the SSRI, fluoxetine, was tested for the ability to protect cortical neurons against 1 ?M oligomeric A?(1-42)-induced toxicity. At therapeutic concentrations (100 nM-1 ?M), fluoxetine significantly prevented A?-induced toxicity in mixed glia-neuronal cultures, but not in pure neuronal cultures. Though to a lesser extent, also sertraline was neuroprotective in mixed cultures, whereas serotonin (10 nM-10 ?M) did not mimick fluoxetine effects. Glia-conditioned medium collected from astrocytes challenged with fluoxetine protected pure cortical neurons against A? toxicity. The effect was lost in the presence of a neutralizing antibody against TGF-?1 in the conditioned medium, or when the specific inhibitor of type-1 TGF-?1 receptor, SB431542, was added to pure neuronal cultures. Accordingly, a 24 h treatment of cortical astrocytes with fluoxetine promoted the release of active TGF-?1 in the culture media through the conversion of latent TGF-?1 to mature TGF-?1. Unlike fluoxetine, both serotonin and sertraline did not stimulate the astrocyte release of active TGF-?1. We conclude that fluoxetine is neuroprotective against A? toxicity via a paracrine signaling mediated by TGF-?1, which does not result from a simplistic SERT blockade. äFluoxetine Prevents A?(1-42)-Induced Toxicity via a Paracrine Signalin(epmc).pdf DeepDyve Pubget Overpricing