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10.3389/fphys.2016.00494 http://scihub22266oqcxt.onion/10.3389/fphys.2016.00494 C5078798!5078798 !27826255     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27826255 &cmd=llinks): Failed to open stream: HTTP request failed! 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Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function |pdf=|usr=}}{{27826255 }} gab.com Text Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27826255 #FOAvip The dimerization or even oligomerization of G protein coupled receptors (GPCRs) causes ongoing, controversial debates about its functional role and the coupled biophysical, biochemical or biomedical implications. A continously growing number of studies hints to a relation between oligomerization and function of GPCRs and strengthens the assumption that receptor assembly plays a key role in the regulation of protein function. Additionally, progress in the structural analysis of GPCR-G protein and GPCR-ligand interactions allows to distinguish between actively functional and non-signaling complexes. Recent findings further suggest that the surrounding membrane, i.e., its lipid composition may modulate the preferred dimerization interface and as a result the abundance of distinct dimeric conformations. In this review, the association of GPCRs and the role of the membrane in oligomerization will be discussed. An overview of the different reported oligomeric interfaces is provided and their capability for signaling discussed. The currently available data is summarized with regard to the formation of GPCR oligomers, their structures and dependency on the membrane microenvironment as well as the coupling of oligomerization to receptor function. Twit Text FOAVip Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27826255 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27826255 #FOAvip English Wikipedia <ref>{{Cite pmid|27826255 }}</ref> Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function #MMPMID27826255 Gahbauer S ; Böckmann RA Front Physiol 2016[]; 7 (ä): 494 PMID27826255 show ga The dimerization or even oligomerization of G protein coupled receptors (GPCRs) causes ongoing, controversial debates about its functional role and the coupled biophysical, biochemical or biomedical implications. A continously growing number of studies hints to a relation between oligomerization and function of GPCRs and strengthens the assumption that receptor assembly plays a key role in the regulation of protein function. Additionally, progress in the structural analysis of GPCR-G protein and GPCR-ligand interactions allows to distinguish between actively functional and non-signaling complexes. Recent findings further suggest that the surrounding membrane, i.e., its lipid composition may modulate the preferred dimerization interface and as a result the abundance of distinct dimeric conformations. In this review, the association of GPCRs and the role of the membrane in oligomerization will be discussed. An overview of the different reported oligomeric interfaces is provided and their capability for signaling discussed. The currently available data is summarized with regard to the formation of GPCR oligomers, their structures and dependency on the membrane microenvironment as well as the coupling of oligomerization to receptor function. äMembrane-Mediated Oligomerization of G Protein Coupled Receptors and I(epmc).pdf DeepDyve Pubget Overpricing