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10.1016/j.ebiom.2016.09.003

http://scihub22266oqcxt.onion/10.1016/j.ebiom.2016.09.003
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C5078588!5078588!27628668
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suck abstract from ncbi


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pmid27628668      EBioMedicine 2016 ; 12 (ä): 178-88
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  • Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool #MMPMID27628668
  • Appanna R; KG S; Xu MH; Toh YX; Velumani S; Carbajo D; Lee CY; Zuest R; Balakrishnan T; Xu W; Lee B; Poidinger M; Zolezzi F; Leo YS; Thein TL; Wang CI; Fink K
  • EBioMedicine 2016[Oct]; 12 (ä): 178-88 PMID27628668show ga
  • Dengue is endemic in tropical countries worldwide and the four dengue virus serotypes often co-circulate. Infection with one serotype results in high titers of cross-reactive antibodies produced by plasmablasts, protecting temporarily against all serotypes, but impairing protective immunity in subsequent infections. To understand the development of these plasmablasts, we analyzed virus-specific B cell properties in patients during acute disease and at convalescence. Plasmablasts were unrelated to classical memory cells expanding in the blood during early recovery. We propose that only a small subset of memory B cells is activated as plasmablasts during repeat infection and that plasmablast responses are not representative of the memory B cell repertoire after dengue infection.
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