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10.1016/j.ebiom.2016.09.003

http://scihub22266oqcxt.onion/10.1016/j.ebiom.2016.09.003
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suck abstract from ncbi


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pmid27628668
      EBioMedicine 2016 ; 12 (ä): 178-188
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  • Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool #MMPMID27628668
  • Appanna R ; Kg S ; Xu MH ; Toh YX ; Velumani S ; Carbajo D ; Lee CY ; Zuest R ; Balakrishnan T ; Xu W ; Lee B ; Poidinger M ; Zolezzi F ; Leo YS ; Thein TL ; Wang CI ; Fink K
  • EBioMedicine 2016[Oct]; 12 (ä): 178-188 PMID27628668 show ga
  • Dengue is endemic in tropical countries worldwide and the four dengue virus serotypes often co-circulate. Infection with one serotype results in high titers of cross-reactive antibodies produced by plasmablasts, protecting temporarily against all serotypes, but impairing protective immunity in subsequent infections. To understand the development of these plasmablasts, we analyzed virus-specific B cell properties in patients during acute disease and at convalescence. Plasmablasts were unrelated to classical memory cells expanding in the blood during early recovery. We propose that only a small subset of memory B cells is activated as plasmablasts during repeat infection and that plasmablast responses are not representative of the memory B cell repertoire after dengue infection.
  • |*Immunologic Memory [MESH]
  • |Acute Disease [MESH]
  • |Animals [MESH]
  • |Antibodies, Viral/genetics/immunology [MESH]
  • |Antibody Specificity/immunology [MESH]
  • |Antigens, Viral/immunology [MESH]
  • |B-Lymphocyte Subsets/*immunology/metabolism [MESH]
  • |Cell Line [MESH]
  • |Clonal Evolution [MESH]
  • |Cross Reactions/immunology [MESH]
  • |Dengue Virus/*immunology [MESH]
  • |Dengue/genetics/*immunology/*virology [MESH]
  • |Humans [MESH]
  • |Immunoglobulin G/genetics/immunology [MESH]
  • |Immunoglobulin Heavy Chains/genetics/immunology [MESH]
  • |Immunoglobulin Variable Region/genetics [MESH]
  • |Immunophenotyping [MESH]
  • |Neutralization Tests [MESH]
  • |Phenotype [MESH]


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