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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Microbiol
2016 ; 54
(11
): 2689-2694
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gab.com Text
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English Wikipedia
Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium
difficile Infection
#MMPMID27558181
Stevenson EC
; Major GA
; Spiller RC
; Kuehne SA
; Minton NP
J Clin Microbiol
2016[Nov]; 54
(11
): 2689-2694
PMID27558181
show ga
Clostridium difficile (Peptoclostridium difficile) is a common health
care-associated infection with a disproportionately high incidence in elderly
patients. Disease symptoms range from mild diarrhea to life-threatening
pseudomembranous colitis. Around 20% of patients may suffer recurrent disease,
which often requires rehospitalization of patients. C. difficile was isolated
from stool samples from a patient with two recurrent C. difficile infections. PCR
ribotyping, whole-genome sequencing, and phenotypic assays were used to
characterize these isolates. Genotypic and phenotypic screening of C. difficile
isolates revealed multiple PCR ribotypes present and the emergence of rifamycin
resistance during the infection cycle. Understanding both the clinical and
bacterial factors that contribute to the course of recurrent infection could
inform strategies to reduce recurrence. (This study has been registered at
ClinicalTrials.gov under registration no. NCT01670149.).