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2016 ; 11
(10
): e0165207
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Epidemiological and Clinical Features of Severe Fever with Thrombocytopenia
Syndrome in Japan, 2013-2014
#MMPMID27776187
Kato H
; Yamagishi T
; Shimada T
; Matsui T
; Shimojima M
; Saijo M
; Oishi K
PLoS One
2016[]; 11
(10
): e0165207
PMID27776187
show ga
Although severe fever with thrombocytopenia syndrome (SFTS) was first reported
from Japan in 2013, the precise clinical features and the risk factors for SFTS
have not been fully investigated in Japan. Ninety-six cases of severe fever with
thrombocytopenia syndrome (SFTS) were notified through the national surveillance
system between April 2013 and September 2014 in Japan. All cases were from
western Japan, and 82 cases (85%) had an onset between April and August. A
retrospective observational study of the notified SFTS cases was conducted to
identify the clinical features and laboratory findings during the same period. Of
96 notified cases, 49 (51%) were included in this study. Most case-patients were
of advanced age (median age 78 years) and were retired or unemployed, or farmers.
These case-patients had a history of outdoor activity within 2 weeks before the
onset of illness. The median serum C-reactive protein concentration was slightly
elevated at admission. Fungal infections such as invasive aspergilosis were found
in 10% of these case-patients. Hemophagocytosis was observed in 15 of the 18
case-patients (83%) whose bone marrow samples were available. Fifteen cases were
fatal, giving a case-fatality proportion of 31%. The proportion of neurological
abnormalities and serum concentrations of lactate dehydrogenase and aspartate
aminotransferase were significantly higher in the fatal cases than in the
nonfatal cases during hospitalization. Appearance of neurological abnormality may
be useful for predicting the prognosis in SFTS patients.