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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Ther+Adv+Chronic+Dis 2016 ; 7 (6): 260-77 Nephropedia Template TP
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Mepolizumab for severe refractory eosinophilic asthma: evidence to date and clinical potential #MMPMID27803792
Menzella F; Lusuardi M; Galeone C; Taddei S; Facciolongo N; Zucchi L
Ther Adv Chronic Dis 2016[Nov]; 7 (6): 260-77 PMID27803792show ga
Severe asthma is characterized by major impairment of quality of life, poor symptom control and frequent exacerbations. Inflammatory, clinical and causative factors identify different phenotypes and endotypes of asthma. In the last few years, new treatment options have allowed for targeted treatments according to the different phenotypes of the disease. To accurately select a specific treatment for each asthmatic variant, the identification of appropriate biomarkers is required. Eosinophilic asthma is a distinct phenotype characterized by thickening of the basement membrane and corticosteroid responsiveness. This review reports the latest evidence on an anti-IL-5 monoclonal antibody, mepolizumab, a new and promising biological agent recently approved by the FDA specifically for the treatment of severe eosinophilic refractory asthma.