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10.1074/jbc.R116.735894 http://scihub22266oqcxt.onion/10.1074/jbc.R116.735894 C5076498!5076498!27462077     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2016 ; 291 (40): 20849-57 Nephropedia Template TP {{tp|p=27462077|t=2016. Why Calcium? How Calcium Became the Best Communicator* |pdf=|usr=}}{{27462077}} gab.com Text Why Calcium How Calcium Became the Best Communicator* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27462077 #FOAvip Calcium carries messages to virtually all important functions of cells. Although it was already active in unicellular organisms, its role became universally important after the transition to multicellular life. In this Minireview, we explore how calcium ended up in this privileged position. Most likely its unique coordination chemistry was a decisive factor as it makes its binding by complex molecules particularly easy even in the presence of large excesses of other cations, e.g. magnesium. Its free concentration within cells can thus be maintained at the very low levels demanded by the signaling function. A large cadre of proteins has evolved to bind or transport calcium. They all contribute to buffer it within cells, but a number of them also decode its message for the benefit of the target. The most important of these ?calcium sensors? are the EF-hand proteins. Calcium is an ambivalent messenger. Although essential to the correct functioning of cell processes, if not carefully controlled spatially and temporally within cells, it generates variously severe cell dysfunctions, and even cell death. Twit Text FOAVip Why Calcium How Calcium Became the Best Communicator* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27462077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27462077 #FOAvip English Wikipedia <ref>{{Cite pmid|27462077}}</ref> Why Calcium? How Calcium Became the Best Communicator* #MMPMID27462077 Carafoli E; Krebs J J Biol Chem 2016[Sep]; 291 (40): 20849-57 PMID27462077show ga Calcium carries messages to virtually all important functions of cells. Although it was already active in unicellular organisms, its role became universally important after the transition to multicellular life. In this Minireview, we explore how calcium ended up in this privileged position. Most likely its unique coordination chemistry was a decisive factor as it makes its binding by complex molecules particularly easy even in the presence of large excesses of other cations, e.g. magnesium. Its free concentration within cells can thus be maintained at the very low levels demanded by the signaling function. A large cadre of proteins has evolved to bind or transport calcium. They all contribute to buffer it within cells, but a number of them also decode its message for the benefit of the target. The most important of these ?calcium sensors? are the EF-hand proteins. Calcium is an ambivalent messenger. Although essential to the correct functioning of cell processes, if not carefully controlled spatially and temporally within cells, it generates variously severe cell dysfunctions, and even cell death. äWhy Calcium? How Calcium Became the Best Communicator* (epmc).pdf DeepDyve Pubget Overpricing