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10.1074/jbc.M116.727701 http://scihub22266oqcxt.onion/10.1074/jbc.M116.727701 C5076495!5076495!27497435     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2016 ; 291 (40): 20827-37 Nephropedia Template TP {{tp|p=27497435|t=2016. Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis* |pdf=|usr=}}{{27497435}} gab.com Text Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27497435 #FOAvip Mitochondria are essential organelles that adapt to stress and environmental changes. Among the nutrient signals that affect mitochondrial form and function is iron, whose depletion initiates a rapid and reversible decrease in mitochondrial biogenesis through unclear means. Here we demonstrate that, unlike the canonical iron-induced alterations to transcript stability, loss of iron dampens the transcription of genes encoding mitochondrial proteins with no change to transcript half-life. Using mass spectrometry, we demonstrate that these transcriptional changes are accompanied by dynamic alterations to histone acetylation and methylation levels that are largely reversible upon readministration of iron. Moreover, histone deacetylase inhibition abrogates the decreased histone acetylation observed upon iron deprivation and restores normal transcript levels at genes encoding mitochondrial proteins. Collectively, we demonstrate that deprivation of an essential nutrient induces transcriptional repression of organellar biogenesis involving epigenetic alterations. Twit Text FOAVip Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=27497435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27497435 #FOAvip English Wikipedia <ref>{{Cite pmid|27497435}}</ref> Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis* #MMPMID27497435 Rensvold JW; Krautkramer KA; Dowell JA; Denu JM; Pagliarini DJ J Biol Chem 2016[Sep]; 291 (40): 20827-37 PMID27497435show ga Mitochondria are essential organelles that adapt to stress and environmental changes. Among the nutrient signals that affect mitochondrial form and function is iron, whose depletion initiates a rapid and reversible decrease in mitochondrial biogenesis through unclear means. Here we demonstrate that, unlike the canonical iron-induced alterations to transcript stability, loss of iron dampens the transcription of genes encoding mitochondrial proteins with no change to transcript half-life. Using mass spectrometry, we demonstrate that these transcriptional changes are accompanied by dynamic alterations to histone acetylation and methylation levels that are largely reversible upon readministration of iron. Moreover, histone deacetylase inhibition abrogates the decreased histone acetylation observed upon iron deprivation and restores normal transcript levels at genes encoding mitochondrial proteins. Collectively, we demonstrate that deprivation of an essential nutrient induces transcriptional repression of organellar biogenesis involving epigenetic alterations. äIron Deprivation Induces Transcriptional Regulation of Mitochondrial B(epmc).pdf DeepDyve Pubget Overpricing