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10.3389/fimmu.2016.00434 http://scihub22266oqcxt.onion/10.3389/fimmu.2016.00434 C5075764!5075764!27822210     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27822210|t=2016. Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis |pdf=|usr=}}{{27822210}} gab.com Text Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27822210 #FOAvip Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease progression may accelerate discovery of adjunct host-directed therapies (HDTs) that will boost current treatment protocols. HDTs focus on potentiating key components of host anti-mycobacterial effector mechanisms, and limiting inflammation and pathological damage in the lung. Granulomas represent a pathological hallmark of TB. They are comprised of impressive arrangement of immune cells that serve to contain the invading pathogen. However, granulomas can also undergo changes, developing caseums and cavities that facilitate bacterial spread and disease progression. Here, we review current concepts on the role of granulomas in pathogenesis and protective immunity against TB, drawing from recent clinical studies in humans and animal models. We also discuss therapeutic potential of inflammatory pathways that drive granuloma progression, with a focus on new and existing drugs that will likely improve TB treatment outcomes. Twit Text FOAVip Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27822210 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27822210 #FOAvip English Wikipedia <ref>{{Cite pmid|27822210}}</ref> Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis #MMPMID27822210 Ndlovu H; Marakalala MJ Front Immunol 2016[]; 7 (ä): ä PMID27822210show ga Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease progression may accelerate discovery of adjunct host-directed therapies (HDTs) that will boost current treatment protocols. HDTs focus on potentiating key components of host anti-mycobacterial effector mechanisms, and limiting inflammation and pathological damage in the lung. Granulomas represent a pathological hallmark of TB. They are comprised of impressive arrangement of immune cells that serve to contain the invading pathogen. However, granulomas can also undergo changes, developing caseums and cavities that facilitate bacterial spread and disease progression. Here, we review current concepts on the role of granulomas in pathogenesis and protective immunity against TB, drawing from recent clinical studies in humans and animal models. We also discuss therapeutic potential of inflammatory pathways that drive granuloma progression, with a focus on new and existing drugs that will likely improve TB treatment outcomes. äGranulomas and Inflammation: Host-Directed Therapies for Tuberculosis (epmc).pdf DeepDyve Pubget Overpricing