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10.1186/s12348-016-0106-z

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suck abstract from ncbi


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pmid27771870
      J+Ophthalmic+Inflamm+Infect 2016 ; 6 (1 ): 39
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  • Disseminated nontuberculous mycobacterial infection with multifocal retinitis and vasculitis in an immunocompromised patient with anti-IFN-? autoantibodies #MMPMID27771870
  • Lee TL ; Agrawal R ; Tan JY ; Ong KH ; Wong CS ; Ho SL
  • J Ophthalmic Inflamm Infect 2016[Dec]; 6 (1 ): 39 PMID27771870 show ga
  • BACKGROUND: Nontuberculous mycobacteria (NTM) are found ubiquitously in the environment. Since exposure to NTM is universal, infection likely represents underlying host susceptibility factors. Anti-IFN-? autoantibodies have been described previously in patients with NTM. Up to 88 % of patients with disseminated NTM or other opportunistic infections have high-titer anti-IFN-? autoantibodies, compared with 2 % of patients with TB and healthy controls. FINDINGS: We report a unique presentation of a patient with anti-IFN-? autoantibodies with disseminated NTM infection who presents with panuveitis with multifocal retinitis and vasculitis. Treatment with systemic anti tubercular therapy resulted in complete clinical resolution with good visual recovery. CONCLUSIONS: Patients with anti-IFN-? autoantibodies present with a novel syndrome that links autoimmunity and immunodeficiency. This case emphasizes the importance of testing for anti-IFN-? autoantibodies in patients with disseminated mycobacterial infection.
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