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10.1186/s10194-016-0692-z

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suck abstract from ncbi


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pmid27771875
      J+Headache+Pain 2016 ; 17 (1 ): 98
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  • Increased default mode network connectivity and increased regional homogeneity in migraineurs without aura #MMPMID27771875
  • Zhang J ; Su J ; Wang M ; Zhao Y ; Yao Q ; Zhang Q ; Lu H ; Zhang H ; Wang S ; Li GF ; Wu YL ; Liu FD ; Shi YH ; Li J ; Liu JR ; Du X
  • J Headache Pain 2016[Dec]; 17 (1 ): 98 PMID27771875 show ga
  • BACKGROUND: The precuneus/posterior cingulate cortex, which has been associated with pain sensitivity, plays a pivotal role in the default mode network. However, information regarding migraine-related alterations in resting-state brain functional connectivity in the default mode network and in local regional spontaneous neuronal activity is not adequate. METHODS: This study used functional magnetic resonance imaging to acquire resting-state scans in 22 migraineurs without aura and in 22 healthy matched controls. Independent component analysis, a data-driven method, was used to calculate the resting-state functional connectivity of the default mode network in the patient and healthy control groups. Regional homogeneity (ReHo) was used to analyse the local features of spontaneous resting-state brain activity in the migraineurs without aura. RESULTS: Compared with the healthy controls, migraineurs without aura showed increased functional connectivity in the left precuneus/posterior cingulate cortex within the default mode network and significant increase in ReHo values in the bilateral precuneus/posterior cingulate cortex, left pons and trigeminal nerve entry zone. In addition, functional connectivity was decreased between the areas with abnormal ReHo (using the peaks in the precuneus/posterior cingulate cortex) and other brain areas. CONCLUSIONS: The abnormalities in the precuneus/posterior cingulate cortex suggest that migraineurs without aura may exhibit information transfer and multimodal integration dysfunction and that pain sensitivity and pian processing may also be affected.
  • |Adult [MESH]
  • |Brain Mapping [MESH]
  • |Brain/*physiopathology [MESH]
  • |Case-Control Studies [MESH]
  • |Female [MESH]
  • |Functional Laterality [MESH]
  • |Functional Neuroimaging [MESH]
  • |Gyrus Cinguli/physiopathology [MESH]
  • |Humans [MESH]
  • |Image Processing, Computer-Assisted [MESH]
  • |Magnetic Resonance Imaging [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Migraine with Aura/*physiopathology [MESH]
  • |Neural Pathways/physiopathology [MESH]
  • |Parietal Lobe/physiopathology [MESH]
  • |Pons/physiopathology [MESH]


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