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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Headache+Pain
2016 ; 17
(1
): 98
Nephropedia Template TP
gab.com Text
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English Wikipedia
Increased default mode network connectivity and increased regional homogeneity in
migraineurs without aura
#MMPMID27771875
Zhang J
; Su J
; Wang M
; Zhao Y
; Yao Q
; Zhang Q
; Lu H
; Zhang H
; Wang S
; Li GF
; Wu YL
; Liu FD
; Shi YH
; Li J
; Liu JR
; Du X
J Headache Pain
2016[Dec]; 17
(1
): 98
PMID27771875
show ga
BACKGROUND: The precuneus/posterior cingulate cortex, which has been associated
with pain sensitivity, plays a pivotal role in the default mode network. However,
information regarding migraine-related alterations in resting-state brain
functional connectivity in the default mode network and in local regional
spontaneous neuronal activity is not adequate. METHODS: This study used
functional magnetic resonance imaging to acquire resting-state scans in 22
migraineurs without aura and in 22 healthy matched controls. Independent
component analysis, a data-driven method, was used to calculate the resting-state
functional connectivity of the default mode network in the patient and healthy
control groups. Regional homogeneity (ReHo) was used to analyse the local
features of spontaneous resting-state brain activity in the migraineurs without
aura. RESULTS: Compared with the healthy controls, migraineurs without aura
showed increased functional connectivity in the left precuneus/posterior
cingulate cortex within the default mode network and significant increase in ReHo
values in the bilateral precuneus/posterior cingulate cortex, left pons and
trigeminal nerve entry zone. In addition, functional connectivity was decreased
between the areas with abnormal ReHo (using the peaks in the precuneus/posterior
cingulate cortex) and other brain areas. CONCLUSIONS: The abnormalities in the
precuneus/posterior cingulate cortex suggest that migraineurs without aura may
exhibit information transfer and multimodal integration dysfunction and that pain
sensitivity and pian processing may also be affected.