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10.1038/ni.3553 http://scihub22266oqcxt.onion/10.1038/ni.3553 C5074366!5074366!27618553     free     free     free       Nat+Immunol 2016 ; 17 (11): 1291-9 Nephropedia Template TP {{tp|p=27618553|t=2016. Evidence of innate lymphoid cell redundancy in humans |pdf=|usr=}}{{27618553}} gab.com Text Evidence of innate lymphoid cell redundancy in humans JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27618553 #FOAvip Innate lymphoid cells (ILCs) have potent immune functions in experimental conditions in mice, but their contribution to immunity in natural conditions in humans remains unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in SCID patients carrying mutations of IL2RG or JAK3. T cell reconstitution was observed in SCID patients upon hematopoietic stem cell transplantation (HSCT), but the patients still exhibited drastic reduction of ILCs in the absence of myeloablation, at the exception of rare cases of ILC1 reconstitution. Remarkably, the observed ILC deficiencies were not associated with any particular susceptibility to disease, with a follow-up extending from 7 to 39 years after HSCT. We thus report here the first cases of selective ILC deficiency in humans, and show that ILCs may be dispensable in natural conditions, if T cells are present and B cell function is preserved. Twit Text FOAVip Evidence of innate lymphoid cell redundancy in humans ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27618553 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27618553 #FOAvip English Wikipedia <ref>{{Cite pmid|27618553}}</ref> Evidence of innate lymphoid cell redundancy in humans #MMPMID27618553 Vély F; Barlogis V; Vallentin B; Neven B; Piperoglou C; Perchet T; Petit M; Yessaad N; Touzot F; Bruneau J; Mahlaoui N; Zucchini N; Farnarier C; Michel G; Moshous D; Blanche S; Dujardin A; Spits H; Distler JHW; Ramming A; Picard C; Golub R; Fischer A; Vivier E Nat Immunol 2016[Nov]; 17 (11): 1291-9 PMID27618553show ga Innate lymphoid cells (ILCs) have potent immune functions in experimental conditions in mice, but their contribution to immunity in natural conditions in humans remains unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in SCID patients carrying mutations of IL2RG or JAK3. T cell reconstitution was observed in SCID patients upon hematopoietic stem cell transplantation (HSCT), but the patients still exhibited drastic reduction of ILCs in the absence of myeloablation, at the exception of rare cases of ILC1 reconstitution. Remarkably, the observed ILC deficiencies were not associated with any particular susceptibility to disease, with a follow-up extending from 7 to 39 years after HSCT. We thus report here the first cases of selective ILC deficiency in humans, and show that ILCs may be dispensable in natural conditions, if T cells are present and B cell function is preserved. äEvidence of innate lymphoid cell redundancy in humans (epmc).pdf DeepDyve Pubget Overpricing