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10.1200/JCO.2012.46.8371

http://scihub22266oqcxt.onion/10.1200/JCO.2012.46.8371
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C5073383!5073383!23752105
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suck abstract from ncbi


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pmid23752105      J+Clin+Oncol 2013 ; 31 (20): 2563-8
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  • Critical Evaluation of Oncology Clinical Practice Guidelines #MMPMID23752105
  • Reames BN; Krell RW; Ponto SN; Wong SL
  • J Clin Oncol 2013[Jul]; 31 (20): 2563-8 PMID23752105show ga
  • Purpose: Significant concerns exist regarding the content and reliability of oncology clinical practice guidelines (CPGs). The Institute of Medicine (IOM) report ?Clinical Practice Guidelines We Can Trust? established standards for developing trustworthy CPGs. By using these standards as a benchmark, we sought to evaluate recent oncology guidelines. Methods: CPGs and consensus statements addressing the screening, evaluation, or management of the four leading causes of cancer-related mortality in the United States (lung, breast, prostate, and colorectal cancers) published between January 2005 and December 2010 were identified. A standardized scoring system based on the eight IOM standards was used to critically evaluate the methodology, content, and disclosure policies of CPGs. All CPGs were given two scores; points were awarded for eight standards and 20 subcriteria. Results: No CPG fully met all the IOM standards. The average overall scores were 2.75 of 8 possible standards and 8.24 of 20 possible subcriteria. Less than half the CPGs were based on a systematic review. Only half the CPG panels addressed conflicts of interest. Most did not comply with standards for inclusion of patient and public involvement in the development or review process, nor did they specify their process for updating. CPGs were most consistent with IOM standards for transparency, articulation of recommendations, and use of external review. Conclusion: The vast majority of oncology CPGs fail to meet the IOM standards for trustworthy guidelines. On the basis of these results, there is still much to be done to make guidelines as methodologically sound and evidence-based as possible.
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