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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Diagn+Res 2016 ; 10 (9): ED04-5 Nephropedia Template TP
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Amyloidosis: The Newer Discovered ALECT2 Associated with der7q add(7) #MMPMID27790444
Chakrabarti A; Samal P; Chakrabartty J
J Clin Diagn Res 2016[Sep]; 10 (9): ED04-5 PMID27790444show ga
Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. ALECT 2 is the newest protein described, having a predisposition to affect the kidneys, sometimes the liver and rarely other organs. We present a case of renal amyloid ALECT 2 due to leucocyte cell derived chemotaxin 2, a novel amyloidogenic protein. The patient presented with mild proteinuria, scattered plasma cells on bone marrow examination and altered kappa/lambda ratio with associated cytogenetic abnormality of der7q add(7). It is essential to correctly type this protein and differentiate it from AL during diagnosis for appropriate and effective clinical management.