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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Diagn+Res
2016 ; 10
(9
): BC08-BC11
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A Study to Assess the Validity of Estimation of Serum Ostase Level in
Hyperthyroid and Hypothyroid Cases
#MMPMID27790421
Boruah P
; Baruah AJ
; Hajong R
; Nath CK
; Barman B
; Chutia H
; Sarma K
J Clin Diagn Res
2016[Sep]; 10
(9
): BC08-BC11
PMID27790421
show ga
INTRODUCTION: One of the more specific assessments of the metabolic status of
bone in normal and in disease conditions is the measurement of bone specific
alkaline phosphatase or ostase. The measurement of serum ostase has several
advantages over the measurements of other bone parameter. Because of its
relatively long half-life, in-vivo (1 to 3days), it is relatively unaffected by
diurnal variation. AIM: To find the correlation of serum ostase level in hyper
and hypothyroid cases and also to study the validity of routine estimation of
serum ostase in hyper and hypothyroid cases so as to monitor the base level bone
health on presentation. MATERIALS AND METHODS: Serum ostase level was studied in
74 patients with disorder of thyroid function. Serum ostase level, Thyroid
Stimulating Hormone (TSH), FT3, FT4 levels were estimated by chemiluminescent
technique. The instrument used was Beckman- coulter Access 2. A total of 39
patients were hypothyroid, 31 were hyperthyroid and 4 patients had subclinical
hyperthyroidism. RESULTS: The serum ostase level was found to be elevated above
40 ?g/L in 26 of the cases and above 16 ?g/L but below 40?g/L in 5 cases of
hyperthyroidism along with decrease in Bone Mineral Density (BMD). Serum ostase
level was found to be directly proportional to the serum FT3 level (Normal range
of serum ostase is 8-16 ?g/L). CONCLUSION: From this study, an inference can be
drawn that a routine estimation of serum ostase level in hyperthyroid cases will
help in proper monitoring of decrease bone turnover as indicated by increase
serum ostase level. Besides, the estimation of serum ostase level in hyperthyroid
cases it is found to be valid in this study, which can turn to be an important
guiding parameter to the treating physician to formulate necessary protocols and
guidelines for prophylaxis, treatment and to monitor the response to therapy in
cases of reduced bone turnover related to hyperthyroid state.