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10.1002/eji.201545939 http://scihub22266oqcxt.onion/10.1002/eji.201545939 C5071739!5071739 !26990545     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26990545 &cmd=llinks): Failed to open stream: HTTP request failed! 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IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells |pdf=|usr=}}{{26990545 }} gab.com Text IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26990545 #FOAvip Immune responses to protein antigens involve CD4(+) and CD8(+) T cells, which follow distinct programs of differentiation. Naïve CD8 T cells rapidly develop cytotoxic T-cell (CTL) activity after T-cell receptor stimulation, and we have previously shown that this is accompanied by suppressive activity in the presence of specific cytokines, i.e. IL-12 and IL-4. Cytokine-induced CD8(+) regulatory T (Treg) cells are one of several Treg-cell phenotypes and are Foxp3(-) IL-10(+) with contact-dependent suppressive capacity. Here, we show they also express high level CD39, an ecto-nucleotidase that degrades extracellular ATP, and this contributes to their suppressive activity. CD39 expression was found to be upregulated on CD8(+) T cells during peripheral tolerance induction in vivo, accompanied by release of IL-12 and IL-10. CD39 was also upregulated during respiratory tolerance induction to inhaled allergen and on tumor-infiltrating CD8(+) T cells. Production of IL-10 and expression of CD39 by CD8(+) T cells was independently regulated, being respectively blocked by extracellular ATP and enhanced by an A2A adenosine receptor agonist. Our results suggest that any CTL can develop suppressive activity when exposed to specific cytokines in the absence of alarmins. Thus negative feedback controls CTL expansion under regulation from both nucleotide and cytokine environment within tissues. Twit Text FOAVip IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26990545 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26990545 #FOAvip English Wikipedia <ref>{{Cite pmid|26990545 }}</ref> IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells #MMPMID26990545 Noble A ; Mehta H ; Lovell A ; Papaioannou E ; Fairbanks L Eur J Immunol 2016[Jun]; 46 (6 ): 1438-48 PMID26990545 show ga Immune responses to protein antigens involve CD4(+) and CD8(+) T cells, which follow distinct programs of differentiation. Naïve CD8 T cells rapidly develop cytotoxic T-cell (CTL) activity after T-cell receptor stimulation, and we have previously shown that this is accompanied by suppressive activity in the presence of specific cytokines, i.e. IL-12 and IL-4. Cytokine-induced CD8(+) regulatory T (Treg) cells are one of several Treg-cell phenotypes and are Foxp3(-) IL-10(+) with contact-dependent suppressive capacity. Here, we show they also express high level CD39, an ecto-nucleotidase that degrades extracellular ATP, and this contributes to their suppressive activity. CD39 expression was found to be upregulated on CD8(+) T cells during peripheral tolerance induction in vivo, accompanied by release of IL-12 and IL-10. CD39 was also upregulated during respiratory tolerance induction to inhaled allergen and on tumor-infiltrating CD8(+) T cells. Production of IL-10 and expression of CD39 by CD8(+) T cells was independently regulated, being respectively blocked by extracellular ATP and enhanced by an A2A adenosine receptor agonist. Our results suggest that any CTL can develop suppressive activity when exposed to specific cytokines in the absence of alarmins. Thus negative feedback controls CTL expansion under regulation from both nucleotide and cytokine environment within tissues. |*Immune Tolerance [MESH] |Adenosine Triphosphate/metabolism [MESH] |Animals [MESH] |Antigens, CD/*metabolism [MESH] |Apyrase/*metabolism [MESH] |CD8-Positive T-Lymphocytes/cytology/drug effects/*immunology/*metabolism [MESH] |Cell Differentiation/drug effects/immunology [MESH] |Female [MESH] |Interleukin-12/*metabolism/pharmacology [MESH] |Interleukin-4/*metabolism/pharmacology [MESH] |Lymphocyte Activation [MESH] |MAP Kinase Signaling System/drug effects [MESH] |Male [MESH] |Melanoma, Experimental [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Peripheral Tolerance/*immunology [MESH] |Receptors, Purinergic P1/metabolism [MESH] |Signal Transduction [MESH] |T-Lymphocyte Subsets/immunology/metabolism [MESH]IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral toleranc(epmc).pdf DeepDyve Pubget Overpricing