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10.1002/ehf2.12088 http://scihub22266oqcxt.onion/10.1002/ehf2.12088 C5071712!5071712 !27818782     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27818782 &cmd=llinks): Failed to open stream: HTTP request failed! 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Randomized pilot trial comparing tolvaptan with furosemide on renal and neurohumoral effects in acute heart failure |pdf=|usr=}}{{27818782 }} gab.com Text Randomized pilot trial comparing tolvaptan with furosemide on renal and neurohumoral effects in acute heart failure JO: ESC Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=27818782 #FOAvip AIMS: Loop diuretics are first-line medications for congestive heart failure (CHF); however, they are associated with serious adverse effects, including decreased renal function, and sympathetic nervous and renin-angiotensin system activation. We tested whether tolvaptan, a vasopressin V2-receptor antagonist, could reduce unfavourable furosemide-induced effects during CHF treatment. METHODS AND RESULTS: Sixty patients emergently hospitalized owing to CHF-induced dyspnea were randomly assigned to receive either 40?mg intravenous furosemide daily or 7.5?mg oral tolvaptan for 5?days after admission. Both groups also received intravenous carperitide and canrenoate potassium. As results, baseline patient characteristics were similar between the furosemide (n?=?30) and the tolvaptan (n?=?30) groups, with no significant difference in 5?day urine volume or fluid balance. Brain natriuretic peptide and body weight improvements were similar between groups. However, serum creatinine (Cr) level did not increase, and the incidence of worsening renal function was significantly lower in the tolvaptan group. Consequently, the Cr increase to gain 1000?mL urine was 2.5-fold lower in the tolvaptan group. Furthermore, the blood urea nitrogen (BUN)/Cr ratio significantly decreased in the tolvaptan group, suggesting that renal perfusion was preserved, and urea reuptake and passive water reabsorption were suppressed following tolvaptan treatment. Although catecholamine improvements after treatment were not significantly different, plasma renin activity was enhanced in the furosemide group. CONCLUSIONS: As compared with furosemide, tolvaptan in patients with acute heart failure is associated with comparable decongestion, better preservation of renal function and less activation of renin-angiotensin system. (UMIN 000014134). Twit Text FOAVip Randomized pilot trial comparing tolvaptan with furosemide on renal and neurohumoral effects in acute heart failure ????ESC Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=27818782 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27818782 #FOAvip English Wikipedia <ref>{{Cite pmid|27818782 }}</ref> Randomized pilot trial comparing tolvaptan with furosemide on renal and neurohumoral effects in acute heart failure #MMPMID27818782 Jujo K ; Saito K ; Ishida I ; Furuki Y ; Kim A ; Suzuki Y ; Sekiguchi H ; Yamaguchi J ; Ogawa H ; Hagiwara N ESC Heart Fail 2016[Sep]; 3 (3 ): 177-188 PMID27818782 show ga AIMS: Loop diuretics are first-line medications for congestive heart failure (CHF); however, they are associated with serious adverse effects, including decreased renal function, and sympathetic nervous and renin-angiotensin system activation. We tested whether tolvaptan, a vasopressin V2-receptor antagonist, could reduce unfavourable furosemide-induced effects during CHF treatment. METHODS AND RESULTS: Sixty patients emergently hospitalized owing to CHF-induced dyspnea were randomly assigned to receive either 40?mg intravenous furosemide daily or 7.5?mg oral tolvaptan for 5?days after admission. Both groups also received intravenous carperitide and canrenoate potassium. As results, baseline patient characteristics were similar between the furosemide (n?=?30) and the tolvaptan (n?=?30) groups, with no significant difference in 5?day urine volume or fluid balance. Brain natriuretic peptide and body weight improvements were similar between groups. However, serum creatinine (Cr) level did not increase, and the incidence of worsening renal function was significantly lower in the tolvaptan group. Consequently, the Cr increase to gain 1000?mL urine was 2.5-fold lower in the tolvaptan group. Furthermore, the blood urea nitrogen (BUN)/Cr ratio significantly decreased in the tolvaptan group, suggesting that renal perfusion was preserved, and urea reuptake and passive water reabsorption were suppressed following tolvaptan treatment. Although catecholamine improvements after treatment were not significantly different, plasma renin activity was enhanced in the furosemide group. CONCLUSIONS: As compared with furosemide, tolvaptan in patients with acute heart failure is associated with comparable decongestion, better preservation of renal function and less activation of renin-angiotensin system. (UMIN 000014134). äRandomized pilot trial comparing tolvaptan with furosemide on renal an(epmc).pdf DeepDyve Pubget Overpricing