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10.1002/path.4708 http://scihub22266oqcxt.onion/10.1002/path.4708 C5071654!5071654!26924464     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Pathol 2016 ; 239 (2): 152-61 Nephropedia Template TP {{tp|p=26924464|t=2016. VEGF?D promotes pulmonary oedema in hyperoxic acute lung injury |pdf=|usr=}}{{26924464}} gab.com Text VEGF D promotes pulmonary oedema in hyperoxic acute lung injury JO: J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26924464 #FOAvip Leakage of fluid from blood vessels, leading to oedema, is a key feature of many diseases including hyperoxic acute lung injury (HALI), which can occur when patients are ventilated with high concentrations of oxygen (hyperoxia). The molecular mechanisms driving vascular leak and oedema in HALI are poorly understood. VEGF?D is a protein that promotes blood vessel leak and oedema when overexpressed in tissues, but the role of endogenous VEGF?D in pathological oedema was unknown. To address these issues, we exposed Vegfd?deficient mice to hyperoxia. The resulting pulmonary oedema in Vegfd?deficient mice was substantially reduced compared to wild?type, as was the protein content of bronchoalveolar lavage fluid, consistent with reduced vascular leak. Vegf?d and its receptor Vegfr?3 were more highly expressed in lungs of hyperoxic, versus normoxic, wild?type mice, indicating that components of the Vegf?d signalling pathway are up?regulated in hyperoxia. Importantly, VEGF?D and its receptors were co?localized on blood vessels in clinical samples of human lungs exposed to hyperoxia; hence, VEGF?D may act directly on blood vessels to promote fluid leak. Our studies show that Vegf?d promotes oedema in response to hyperoxia in mice and support the hypothesis that VEGF?D signalling promotes vascular leak in human HALI. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. Twit Text FOAVip VEGF D promotes pulmonary oedema in hyperoxic acute lung injury ????J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26924464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26924464 #FOAvip English Wikipedia <ref>{{Cite pmid|26924464}}</ref> VEGF?D promotes pulmonary oedema in hyperoxic acute lung injury #MMPMID26924464 Sato T; Paquet?Fifield S; Harris NC; Roufail S; Turner DJ; Yuan Y; Zhang Y; Fox SB; Hibbs ML; Wilkinson?Berka JL; Williams RA; Stacker SA; Sly PD; Achen MG J Pathol 2016[Jun]; 239 (2): 152-61 PMID26924464show ga Leakage of fluid from blood vessels, leading to oedema, is a key feature of many diseases including hyperoxic acute lung injury (HALI), which can occur when patients are ventilated with high concentrations of oxygen (hyperoxia). The molecular mechanisms driving vascular leak and oedema in HALI are poorly understood. VEGF?D is a protein that promotes blood vessel leak and oedema when overexpressed in tissues, but the role of endogenous VEGF?D in pathological oedema was unknown. To address these issues, we exposed Vegfd?deficient mice to hyperoxia. The resulting pulmonary oedema in Vegfd?deficient mice was substantially reduced compared to wild?type, as was the protein content of bronchoalveolar lavage fluid, consistent with reduced vascular leak. Vegf?d and its receptor Vegfr?3 were more highly expressed in lungs of hyperoxic, versus normoxic, wild?type mice, indicating that components of the Vegf?d signalling pathway are up?regulated in hyperoxia. Importantly, VEGF?D and its receptors were co?localized on blood vessels in clinical samples of human lungs exposed to hyperoxia; hence, VEGF?D may act directly on blood vessels to promote fluid leak. Our studies show that Vegf?d promotes oedema in response to hyperoxia in mice and support the hypothesis that VEGF?D signalling promotes vascular leak in human HALI. © 2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. äVEGF?D promotes pulmonary oedema in hyperoxic acute lung injury (epmc).pdf DeepDyve Pubget Overpricing