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10.1038/cdd.2016.71 http://scihub22266oqcxt.onion/10.1038/cdd.2016.71 C5071574!5071574 !27447115     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27447115 &cmd=llinks): Failed to open stream: HTTP request failed! 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Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages |pdf=|usr=}}{{27447115 }} gab.com Text Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=27447115 #FOAvip Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease, characterized by chronic inflammatory demyelination in the nervous tissue and subsequent neurological dysfunction. Spermidine, a natural polyamine, has been shown to affect inflammation in some experimental models. We show here that spermidine could alleviate experimental autoimmune encephalomyelitis (EAE), a model for MS, through regulating the infiltration of CD4(+) T cells and macrophages in central nervous system. Unexpectedly, we found that spermidine treatment of MOG-specific T cells did not affect their pathogenic potency upon adaptive transfer; however, spermidine diminished the ability of macrophages in activating MOG-specific T cells ex vivo. Depletion of macrophages in diseased mice completely abolished the therapeutic effect of spermidine, indicating a critical role of spermidine-activated macrophages. Mechanistically, spermidine was found to specifically suppress the expression of interleukin-1beta (IL-1?), IL-12 and CD80 while enhance the expression of arginase 1 in macrophages. Interestingly, macrophages from spermidine-treated mice could also reverse EAE progression, while pretreatment of those macrophages with the arginase 1 inhibitor abrogated the therapeutic effect. Therefore, our studies revealed a critical role of macrophages in spermidine-mediated treatment on EAE and provided novel information for better management of MS. Twit Text FOAVip Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=27447115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27447115 #FOAvip English Wikipedia <ref>{{Cite pmid|27447115 }}</ref> Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages #MMPMID27447115 Yang Q ; Zheng C ; Cao J ; Cao G ; Shou P ; Lin L ; Velletri T ; Jiang M ; Chen Q ; Han Y ; Li F ; Wang Y ; Cao W ; Shi Y Cell Death Differ 2016[Nov]; 23 (11 ): 1850-1861 PMID27447115 show ga Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease, characterized by chronic inflammatory demyelination in the nervous tissue and subsequent neurological dysfunction. Spermidine, a natural polyamine, has been shown to affect inflammation in some experimental models. We show here that spermidine could alleviate experimental autoimmune encephalomyelitis (EAE), a model for MS, through regulating the infiltration of CD4(+) T cells and macrophages in central nervous system. Unexpectedly, we found that spermidine treatment of MOG-specific T cells did not affect their pathogenic potency upon adaptive transfer; however, spermidine diminished the ability of macrophages in activating MOG-specific T cells ex vivo. Depletion of macrophages in diseased mice completely abolished the therapeutic effect of spermidine, indicating a critical role of spermidine-activated macrophages. Mechanistically, spermidine was found to specifically suppress the expression of interleukin-1beta (IL-1?), IL-12 and CD80 while enhance the expression of arginase 1 in macrophages. Interestingly, macrophages from spermidine-treated mice could also reverse EAE progression, while pretreatment of those macrophages with the arginase 1 inhibitor abrogated the therapeutic effect. Therefore, our studies revealed a critical role of macrophages in spermidine-mediated treatment on EAE and provided novel information for better management of MS. |Adoptive Transfer [MESH] |Animals [MESH] |Arginase/metabolism [MESH] |Cell Polarity/drug effects [MESH] |Central Nervous System/immunology/pathology [MESH] |Encephalomyelitis, Autoimmune, Experimental/*drug therapy/*pathology/prevention & control [MESH] |Immunosuppression Therapy [MESH] |Leukocytes/drug effects/pathology [MESH] |Macrophages/drug effects/*pathology [MESH] |Mice, Inbred C57BL [MESH] |Models, Biological [MESH] |NF-kappa B/metabolism [MESH] |Phenotype [MESH] |Signal Transduction/drug effects [MESH]Spermidine alleviates experimental autoimmune encephalomyelitis throug(epmc).pdf DeepDyve Pubget Overpricing