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10.1038/ni.3540 http://scihub22266oqcxt.onion/10.1038/ni.3540 C5071159!5071159!27595233     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2016 ; 17 (11): 1322-33 Nephropedia Template TP {{tp|p=27595233|t=2016. An essential role for IL-2 receptor in regulatory T cell function |pdf=|usr=}}{{27595233}} gab.com Text An essential role for IL-2 receptor in regulatory T cell function JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27595233 #FOAvip Regulatory T (Treg) cells, expressing abundant amounts of the IL-2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature implied a key role for a simple network based on IL-2 consumption by Treg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the Treg cell lineage specification factor Foxp3, confounding experimental efforts to understand the role of IL-2R expression and signaling in Treg suppressor function. Using genetic gain and loss of function approaches, we demonstrate that IL-2 capture is dispensable for control of CD4+ T cells, but is important for limiting CD8+ T cell activation, and that IL-2R dependent STAT5 transcription factor activation plays an essential role in Treg cell suppressor function separable from T cell receptor signaling. Twit Text FOAVip An essential role for IL-2 receptor in regulatory T cell function ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27595233 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27595233 #FOAvip English Wikipedia <ref>{{Cite pmid|27595233}}</ref> An essential role for IL-2 receptor in regulatory T cell function #MMPMID27595233 Chinen T; Kannan AK; Levine AG; Fan X; Klein U; Zheng Y; Gasteiger G; Feng Y; Fontenot JD; Rudensky AY Nat Immunol 2016[Nov]; 17 (11): 1322-33 PMID27595233show ga Regulatory T (Treg) cells, expressing abundant amounts of the IL-2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature implied a key role for a simple network based on IL-2 consumption by Treg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the Treg cell lineage specification factor Foxp3, confounding experimental efforts to understand the role of IL-2R expression and signaling in Treg suppressor function. Using genetic gain and loss of function approaches, we demonstrate that IL-2 capture is dispensable for control of CD4+ T cells, but is important for limiting CD8+ T cell activation, and that IL-2R dependent STAT5 transcription factor activation plays an essential role in Treg cell suppressor function separable from T cell receptor signaling. äAn essential role for IL-2 receptor in regulatory T cell function (epmc).pdf DeepDyve Pubget Overpricing