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10.1007/s00109-016-1461-9 http://scihub22266oqcxt.onion/10.1007/s00109-016-1461-9 C5071157!5071157!27544281     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27544281&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Med+(Berl) 2016 ; 94 (11): 1217-27 Nephropedia Template TP {{tp|p=27544281|t=2016. Autophagy core machinery: overcoming spatial barriers in neurons |pdf=|usr=}}{{27544281}} gab.com Text Autophagy core machinery: overcoming spatial barriers in neurons JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=27544281 #FOAvip Autophagy is a major degradation pathway that engulfs, removes and recycles unwanted cytoplasmic material including damaged organelles and toxic protein aggregates. One type of autophagy, macroautophagy, is a tightly regulated process facilitated by autophagy-related (Atg) proteins that must communicate effectively and act in concert to enable the de novo formation of the phagophore, its maturation into an autophagosome and its subsequent targeting and fusion with the lysosome or the vacuole. Autophagy plays a significant role in physiology and its deregulation has been linked to several diseases, which include certain cancers, cardiomyopathies, and neurodegenerative diseases. Here, we summarize the key processes and the proteins that make up the macroautophagy machinery. We also briefly highlight recently uncovered molecular mechanisms specific to neurons allowing them to uniquely regulate this catabolic process to accommodate their complicated architecture and non-dividing state. Overall, these distinct mechanisms establish a conceptual framework addressing how macroautophagic dysfunction could result in maladies of the nervous system, providing possible therapeutic avenues to explore with a goal of preventing or curing such diseases. Twit Text FOAVip Autophagy core machinery: overcoming spatial barriers in neurons ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=27544281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27544281 #FOAvip English Wikipedia <ref>{{Cite pmid|27544281}}</ref> Autophagy core machinery: overcoming spatial barriers in neurons #MMPMID27544281 Ariosa AR; Klionsky DJ J Mol Med (Berl) 2016[Nov]; 94 (11): 1217-27 PMID27544281show ga Autophagy is a major degradation pathway that engulfs, removes and recycles unwanted cytoplasmic material including damaged organelles and toxic protein aggregates. One type of autophagy, macroautophagy, is a tightly regulated process facilitated by autophagy-related (Atg) proteins that must communicate effectively and act in concert to enable the de novo formation of the phagophore, its maturation into an autophagosome and its subsequent targeting and fusion with the lysosome or the vacuole. Autophagy plays a significant role in physiology and its deregulation has been linked to several diseases, which include certain cancers, cardiomyopathies, and neurodegenerative diseases. Here, we summarize the key processes and the proteins that make up the macroautophagy machinery. We also briefly highlight recently uncovered molecular mechanisms specific to neurons allowing them to uniquely regulate this catabolic process to accommodate their complicated architecture and non-dividing state. Overall, these distinct mechanisms establish a conceptual framework addressing how macroautophagic dysfunction could result in maladies of the nervous system, providing possible therapeutic avenues to explore with a goal of preventing or curing such diseases. äAutophagy core machinery: overcoming spatial barriers in neurons (epmc).pdf DeepDyve Pubget Overpricing