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Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory
roles in the spatiotemporal regulation of autophagy
#MMPMID27418283
Lee YK
; Lee JA
BMB Rep
2016[Aug]; 49
(8
): 424-30
PMID27418283
show ga
Autophagy, an evolutionarily conserved cellular degradation pathway of the
lysosome, is associated with many physiological and pathological processes. The
hallmark of autophagy is the formation of the autophagosome that engulfs and
degrades cytosolic components via its fusion with the lysosome, in either a
selective or a non-selective manner. Autophagy is tightly regulated by proteins
encoded by autophagy-related (atg) genes. Among these proteins, ATG8/ LC3 is
essential for autophagosome biogenesis/maturation and it also functions as an
adaptor protein for selective autophagy. In mammalian cells, several homologs of
yeast Atg8 such as MAP1LC3, GABARAP, and GABARAPL 1/2 have been identified.
However, the biological relevance of this gene diversity in higher eukaryotes,
and their specific roles, are largely unknown. In this review, we describe the
mammalian ATG8/LC3 family and discuss recent advancements in understanding their
roles in the autophagic process. [BMB Reports 2016; 49(8): 424-430].
|*Autophagy
[MESH]
|Animals
[MESH]
|Autophagy-Related Protein 8 Family/chemistry/*metabolism
[MESH]
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