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10.5483/BMBRep.2016.49.8.112 http://scihub22266oqcxt.onion/10.5483/BMBRep.2016.49.8.112 C5070726!5070726!27418286     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMB+Rep 2016 ; 49 (8): 403-4 Nephropedia Template TP {{tp|p=27418286|t=2016. Mechanosensitive ?-catenin signaling regulates lymphatic vascular development |pdf=|usr=}}{{27418286}} gab.com Text Mechanosensitive -catenin signaling regulates lymphatic vascular development JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=27418286 #FOAvip The Wnt/?-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/?-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/?-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). ?-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of ?-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/?-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development. [BMB Reports 2016; 49(8): 403-404] Twit Text FOAVip Mechanosensitive -catenin signaling regulates lymphatic vascular development ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=27418286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27418286 #FOAvip English Wikipedia <ref>{{Cite pmid|27418286}}</ref> Mechanosensitive ?-catenin signaling regulates lymphatic vascular development #MMPMID27418286 Cha B; Srinivasan RS BMB Rep 2016[Aug]; 49 (8): 403-4 PMID27418286show ga The Wnt/?-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/?-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/?-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). ?-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of ?-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/?-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development. [BMB Reports 2016; 49(8): 403-404] äMechanosensitive ?-catenin signaling regulates lymphatic vascular deve(epmc).pdf DeepDyve Pubget Overpricing