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10.1136/esmoopen-2016-000091 http://scihub22266oqcxt.onion/10.1136/esmoopen-2016-000091 C5070272!5070272!27843635     free     free     free       ESMO+Open 2016 ; 1 (4): ä Nephropedia Template TP {{tp|p=27843635|t=2016. Renal insufficiency and cancer treatments |pdf=|usr=}}{{27843635}} gab.com Text Renal insufficiency and cancer treatments JO: ESMO Open http://www.kidney.de/pget.php?&tw=1&pmid=27843635 #FOAvip Renal insufficiency has been shown to be highly prevalent in patients with cancer. This renal insufficiency has been reported to be associated with reduced overall survival and increased cancer-related mortality. Therefore, it is important to screen patients with cancer for renal insufficiency, using an adequate and reliable method of estimation of the renal function. Renal insufficiency may influence 1 or several of the 4 pharmacokinetic phases (absorption, distribution, metabolism, elimination/excretion), potentially resulting in marked modifications of the pharmacokinetic profile of a drug in patients with renal insufficiency. Consequently, it is potentially necessary to adjust the dosage of anticancer drugs in case of renal insufficiency in order to avoid drug accumulation and in order to reduce overdosage-related side effects. This dosage adjustment of anticancer drugs should be performed according to the level of renal function and with an appropriate and validated method. It is not always easy to find clear information on anticancer drug handling in these patients. However, several guidelines, publications and handbooks are available on how to adjust anticancer drug dosages in patients with renal insufficiency and will help practitioners to manage anticancer drugs in such patients. Twit Text FOAVip Renal insufficiency and cancer treatments ????ESMO Open http://www.kidney.de/pget.php?&tw=1&pmid=27843635 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27843635 #FOAvip English Wikipedia <ref>{{Cite pmid|27843635}}</ref> Renal insufficiency and cancer treatments #MMPMID27843635 Launay-Vacher V; Janus N; Deray G ESMO Open 2016[]; 1 (4): ä PMID27843635show ga Renal insufficiency has been shown to be highly prevalent in patients with cancer. This renal insufficiency has been reported to be associated with reduced overall survival and increased cancer-related mortality. Therefore, it is important to screen patients with cancer for renal insufficiency, using an adequate and reliable method of estimation of the renal function. Renal insufficiency may influence 1 or several of the 4 pharmacokinetic phases (absorption, distribution, metabolism, elimination/excretion), potentially resulting in marked modifications of the pharmacokinetic profile of a drug in patients with renal insufficiency. Consequently, it is potentially necessary to adjust the dosage of anticancer drugs in case of renal insufficiency in order to avoid drug accumulation and in order to reduce overdosage-related side effects. This dosage adjustment of anticancer drugs should be performed according to the level of renal function and with an appropriate and validated method. It is not always easy to find clear information on anticancer drug handling in these patients. However, several guidelines, publications and handbooks are available on how to adjust anticancer drug dosages in patients with renal insufficiency and will help practitioners to manage anticancer drugs in such patients. äRenal insufficiency and cancer treatments (epmc).pdf DeepDyve Pubget Overpricing