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2016 ; 1
(3
): e000053
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English Wikipedia
Survey of the management of chemotherapy-induced peripheral neuropathy in Japan:
Japanese Society of Medical Oncology
#MMPMID27843610
Hirayama Y
; Sasaki J
; Dosaka-Akita H
; Ishitani K
ESMO Open
2016[]; 1
(3
): e000053
PMID27843610
show ga
BACKGROUND: Various drugs are administered for the management of
chemotherapy-induced peripheral neuropathy (CIPN) in Japan. However, there have
been no surveys undertaken to identify these drugs or their frequency of
prescription. Therefore, we administered a questionnaire survey to the diplomates
of the Subspecialty Board of Japanese Society of Medical Oncology (JSMO) to
investigate the frequency of administration of different drugs for the management
of CIPN in Japan. METHODS: We investigated the use of vitamin B(12),
antiepileptic agents such as pregabalin, duloxetine, antidepressants other than
duloxetine, non-steroidal anti-inflammatory drugs (NSAIDs), opioids and the Kampo
compound goshajinkigan in a questionnaire employing a three-step scale wherein A
implies routine or prophylactic administration, B implies occasional
administration and C implies infrequent administration. RESULTS: Considering
responses A and B together, the most frequently administered drugs for the
treatment of numbness were antiepileptic drugs such as pregabalin (A+B=98.7%),
vitamin B(12) (74.7%), Kampo compounds (58.7%) and duloxetine (46.8%). The most
frequently prescribed drugs for pain were NSAIDs (97.7%), followed by opioids
(83.1%) and finally antiepileptic drugs (82.1%). CONCLUSIONS: Various drugs are
frequently administered for CIPN. In addition, it was found that marked
differences exist between the drugs targeted on numbness and pain.